Cover [Abstract] Document Information [Table] Document Information [Line Items] Document Type Document Annual Report Document Period End Date Document Transition Report Securities Act File Number Entity Registrant Name Entity Incorporation, State or Country Code Entity Tax Identification Number Entity Address, Address Line One Entity Address, Address Line Two Entity Address, City or Town Entity Address, State or Province Entity Address, Postal Zip Code City Area Code Local Phone Number Title of 12(b) Security Trading Symbol Security Exchange Name Entity Well-known Seasoned Issuer Entity Voluntary Filers Entity Current Reporting Status Entity Interactive Data Current Entity Filer Category Entity Small Business Entity Emerging Growth Company ICFR Auditor Attestation Flag Document Financial Statement Error Correction [Flag] Entity Shell Company Entity Public Float Entity Common Stock, Shares Outstanding Auditor Firm ID Auditor Name Auditor Location Entity Central Index Key Current Fiscal Year End Date Document Fiscal Year Focus Document Fiscal Period Focus Amendment Flag Documents Incorporated by Reference [Text Block] Statement of Financial Position [Abstract] Statement [Table] Statement [Line Items] Assets [Abstract] Assets, Current [Abstract] Current assets: Cash and Cash Equivalent Cash and cash equivalents Debt Securities, Available-for-Sale, Current Short-term marketable securities Represents the amount receivable from collaboration partners under the collaborative arrangement. Receivables from Collaboration Partners Receivables from collaborative arrangements Receivables from Milestone and Royalty Assets, Current Receivables from Milestone and Royalty Assets, Current Receivables from milestones and royalty assets Other Prepaid Expense, Current Other prepaid and current assets Assets, Current Total current assets Debt Securities, Available-for-Sale, Noncurrent Long-term marketable securities Property, Plant and Equipment, Net Property and equipment, net Property and equipment, net Operating Lease, Right-of-Use Asset Operating lease assets Amount of future contingent milestone and royally assets. Future Contingent Milestone and Royalty Assets Future contingent milestone and royalty assets carrying value Future contingent milestone and royalty assets Restricted Cash, Noncurrent Restricted cash Other Assets, Noncurrent Other assets Assets Total assets Liabilities and Equity [Abstract] Liabilities, Current [Abstract] Current liabilities: Accounts Payable, Current Accounts payable Employee-related Liabilities, Current Accrued personnel-related expenses Carrying value as of the balance sheet date of obligations incurred through that date and payable for obligations related to clinical development services. Used to reflect the current portion of the liabilities (due within one year or within the normal operating cycle if longer). Accrued Clinical and Development Expenses, Current Accrued clinical and development expenses Accrued General and Administrative Expenses Accrued General and Administrative Expenses Accrued general and administrative expenses Operating Lease, Liability, Current Operating lease liabilities, current Operating lease liabilities Accrued Income Taxes, Current Income tax payable Other Accrued Liabilities, Current Other accrued liabilities Liabilities, Current Total current liabilities Operating Lease, Liability, Noncurrent Operating lease liabilities, non-current Long-term operating lease liabilities The amount of future royalty payment contingencies. Future Royalty Payment Contingencies Future royalty payment contingency Unrecognized Tax Benefits, Noncurrent Unrecognized Tax Benefits, Noncurrent Unrecognized tax benefits Other Liabilities, Noncurrent Other long-term liabilities Commitments and Contingencies Commitments and contingencies (Note 15) Equity, Attributable to Parent [Abstract] Shareholders' Equity Preferred Stock, Value, Issued Preferred shares, $0.00001 par value per share: 230 shares authorized, no shares issued or outstanding Common Stock, Value, Issued Ordinary shares, $0.00001 par value per share: 200,000 shares authorized; 51,069 and 49,471 shares issued and outstanding at December 31, 2025 and December 31, 2024, respectively Additional Paid in Capital Additional paid-in capital Accumulated Other Comprehensive Income (Loss), Net of Tax Accumulated other comprehensive income Retained Earnings (Accumulated Deficit) Accumulated deficit Equity, Attributable to Parent Total shareholders' equity Liabilities and Equity Total liabilities and shareholders' equity Stockholders' Equity, Number of Shares, Par Value and Other Disclosure [Abstract] Preferred Stock, Number of Shares, Par Value and Other Disclosure [Abstract] Preferred shares Preferred Stock, Par or Stated Value Per Share Preferred shares, par value (in dollars per share) Preferred Stock, Shares Authorized Preferred shares, shares authorized (in shares) Preferred Stock, Shares Issued Preferred shares, shares issued (in shares) Preferred Stock, Shares Outstanding Preferred shares, outstanding shares (in shares) Common Stock, Number of Shares, Par Value and Other Disclosure [Abstract] Ordinary shares Common Stock, Par or Stated Value Per Share Ordinary shares, par value (in dollars per share) Common Stock, Shares Authorized Ordinary shares, shares authorized (in shares) Common Stock, Shares, Issued Balances (in shares) Balances (in shares) Ordinary shares, shares issued (in shares) Common Stock, Shares, Outstanding Ordinary shares, shares outstanding (in shares) Income Statement [Abstract] Product and Service [Axis] Product and Service [Domain] Collaborative Arrangement Revenue [Member] Collaborative Arrangement Revenue [Member] Collaboration Agreement Licensing and Milestone [Member] Licensing and Milestone [Member] Licensing and Milestone Revenues [Abstract] Revenues: Revenue from Contract with Customer, Excluding Assessed Tax Total revenues Operating Expenses [Abstract] Expenses: Research and Development Expense Research and development Selling, General and Administrative Expense Selling, general and administrative Asset Impairment Charges Impairment of long-lived assets (non-cash) Loss on impairment of long-lived assets Operating Expenses Total expenses Total expenses Operating Income (Loss) Loss from operations Loss from operations Nonoperating Income (Expense), Gain (Loss) on Realized Contingent Milestone and Royalty Assets Nonoperating Income (Expense), Gain (Loss) on Realized Contingent Milestone and Royalty Assets Net gain on realized contingent milestone and royalty assets Nonoperating Income (Expense), Milestone Income Nonoperating Income (Expense), Milestone Income TRELEGY milestone income Interest Expense, Nonoperating Interest expense (non-cash) Other Nonoperating Income (Expense) Interest and other income, net Interest and other income, net Income (Loss) from Continuing Operations before Income Taxes, Noncontrolling Interest Income (loss) before income taxes Income Tax Expense (Benefit) Provision for income tax benefit (expense) Total Provision for income tax expense Total Net income (loss) Net income (loss) Earnings Per Share, Diluted [Abstract] Net income (loss) per share: Earnings Per Share, Basic Net income (loss) per share - basic (in dollars per share) Earnings Per Share, Diluted Net income (loss) per share - diluted (in dollars per share) Weighted Average Number of Shares Outstanding, Basic Shares used to compute net income (loss) per share - basic (in shares) Weighted-average ordinary shares outstanding - basic (in shares) Weighted Average Number of Shares Outstanding, Diluted Weighted-average ordinary shares outstanding - diluted (in shares) Shares used to compute net income (loss) per share - diluted (in shares) Statement of Income Location, Balance [Axis] Statement of Income Location, Balance [Domain] Research and Development Expense [Member] Research and Development Selling, General and Administrative Expenses [Member] Selling, General and Administrative Compensation Items [Abstract] Income Statement Compensation Expense Items [Abstract] Share-Based Compensation Expense Share-Based Payment Arrangement, Expense Share-based compensation expense Statement of Comprehensive Income [Abstract] Net Income (Loss) Attributable to Parent [Abstract] Net income (loss) Other Comprehensive Income (Loss), Net of Tax, Portion Attributable to Parent [Abstract] Other comprehensive income: OCI, Debt Securities, Available-for-Sale, Unrealized Holding Gain (Loss), before Adjustment, after Tax Net unrealized gain (loss) on marketable securities Net unrealized gain on available-for-sale investments Comprehensive Income (Loss), Net of Tax, Attributable to Parent Comprehensive income (loss) Statement of Stockholders' Equity [Abstract] Equity Components [Axis] Equity Component [Domain] Parent [Member] Common Stock [Member] Ordinary Shares Additional Paid-in Capital [Member] Additional Paid-In Capital AOCI Attributable to Parent [Member] Accumulated Other Comprehensive Income (Loss) Retained Earnings [Member] Accumulated Deficit Increase (Decrease) in Stockholders' Equity [Roll Forward] Increase (Decrease) in Stockholders' Equity Equity, Including Portion Attributable to Noncontrolling Interest Balances Balances Stock Repurchased and Retired During Period, Value Repurchase of ordinary shares, net of transaction costs Amount repurchased (excluding fees and expenses) Stock Repurchased and Retired During Period, Shares Repurchase of ordinary shares, net of transaction costs (in shares) Shares repurchased (in shares) Stock Issued During Period, Value, New Issues Proceeds from the sale of ordinary shares Stock Issued During Period, Shares, New Issues Proceeds from the sale of ordinary shares (in shares) Stock Issued During Period, Value, Employee Stock Purchase Plan Proceeds from ESPP purchases Stock Issued During Period, Shares, Employee Stock Purchase Plans Proceeds from ESPP purchases (in shares) APIC, Share-Based Payment Arrangement, Increase for Cost Recognition Employee share-based compensation expense Stock Issued During Period, Value, Restricted Stock Award, Gross Issuance of restricted shares Stock Issued During Period, Shares, Restricted Stock Award, Gross Issuance of restricted shares (in shares) Stock Issued During Period, Value, Stock Options Exercised Option exercises Share-Based Compensation Arrangement by Share-Based Payment Award, Options, Exercises in Period Exercised (in shares) Option exercises (in shares) Share-Based Payment Arrangement, Decrease for Tax Withholding Obligation Repurchase of shares to satisfy tax withholding Share-Based Payment Arrangement, Shares Withheld for Tax Withholding Obligation Repurchase of shares to satisfy tax withholding (in shares) Statement of Cash Flows [Abstract] Cash Provided by (Used in) Operating Activity, Continuing Operation [Abstract] Operating activities Net Income (Loss), Including Portion Attributable to Noncontrolling Interest Net income (loss) Adjustment to Reconcile Net Income to Cash Provided by (Used in) Operating Activity [Abstract] Adjustments to reconcile net income (loss) to net cash provided by (used in) operating activities: Other Depreciation and Amortization Depreciation and amortization Amortization and Accretion Income Amortization and Accretion Income Amortization and accretion on investment securities, net The accretion of interest on liability for sale of future royalties. Interest Accretion on Future Royalty Payment Contingencies Future royalty payment contingency interest accretion Share-Based Payment Arrangement, Noncash Expense Share-based compensation Gain (Loss) on Disposition of Property Plant Equipment Loss on disposal of property and equipment Operating Lease, Right-of-Use Asset, Periodic Reduction Amortization of right-of-use assets Deferred Income Taxes and Tax Credits Deferred income taxes Other Noncash Income (Expense) Other Adjustment to Reconcile Net Income to Cash Provided by (Used in) Operating Activity, Increase (Decrease) in Operating Capital [Abstract] Changes in operating assets and liabilities: The increase (decrease) during the reporting period in receivables from collaboration partners. Increase (Decrease) in Receivables from Collaboration Partners Receivables from collaborative and licensing arrangements The increase (decrease) during the reporting period in prepaid clinical and development services. Increase (Decrease) in Prepaid Clinical and Development Services Prepaid clinical and development services Increase (Decrease) in Prepaid Expenses, Other Other prepaid and current assets Amount of increase (decrease) in right-of-use assets for an operating lease. Increase (Decrease) in Right-of-use Assets Right-of-use lease assets Increase (Decrease) in Future Contingent Milestone and Royalty Assets Increase (Decrease) in Future Contingent Milestone and Royalty Assets Future contingent milestone and royalty assets Increase (Decrease) in Other Operating Assets Other assets Increase (Decrease) in Accounts Payable Accounts payable Increase (Decrease) in Accrued Liabilities Accrued personnel-related expenses, accrued clinical and development expenses, and other accrued liabilities Increase (Decrease) in Operating Lease Liability Operating lease liabilities Period Increase (Decrease), Unrecognized Tax Benefits Period Increase (Decrease), Unrecognized Tax Benefits Unrecognized tax benefits Increase (Decrease) in Other Noncurrent Liabilities Other long-term liabilities Cash Provided by (Used in) Operating Activity, Including Discontinued Operation Net cash provided by (used in) operating activities Cash Provided by (Used in) Investing Activity, Continuing Operation [Abstract] Investing activities Payments to Acquire Productive Assets Purchases of property and equipment Payments to Acquire Debt Securities, Available-for-Sale Purchases of marketable securities Proceeds from Sale and Maturity of Debt Securities, Available-for-Sale Maturities of marketable securities Payments for Purchase of Derivative Instrument, Investing Activities Payments for Purchase of Derivative Instrument, Investing Activities Purchase of derivative Proceeds from Sale, Maturity and Collection of Short-Term Investments Sale of short-term investments and marketable securities Cash Provided by (Used in) Investing Activity, Including Discontinued Operation Net cash (used in) provided by investing activities Cash Provided by (Used in) Financing Activity, Continuing Operation [Abstract] Financing activities Payments for Repurchase of Common Stock Ordinary share repurchases Proceeds from Issuance of Common Stock Proceeds from the sale of ordinary shares Proceeds from Stock Plans Proceeds from ESPP purchases Proceeds from Stock Options Exercised Proceeds from option exercises Payment, Tax Withholding, Share-Based Payment Arrangement Repurchase of shares to satisfy tax withholding Cash Provided by (Used in) Financing Activity, Including Discontinued Operation Net cash used in financing activities Cash, Cash Equivalent, Restricted Cash, and Restricted Cash Equivalent, Period Increase (Decrease), Including Exchange Rate Effect and Discontinued Operation Net increase (decrease) in cash, cash equivalents, and restricted cash Cash, Cash Equivalent, Restricted Cash, and Restricted Cash Equivalent, Continuing Operation Cash, cash equivalents, and restricted cash at end of period Cash, cash equivalents, and restricted cash at beginning of period Total cash, cash equivalents, and restricted cash Supplemental Cash Flow Information [Abstract] Supplemental disclosure of cash flow information Income Taxes Paid, Net Cash paid for income taxes, net Total income taxes paid, net