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--12-31
Q1
2016
2016-03-31
10-Q
0001583107
47479910
Yes
Accelerated Filer
Theravance Biopharma, Inc.
14709000
23640000
<div> <div style="margin-left:0%;margin-right:0%;"></div><div style="margin-left:0%;margin-right:0%;">
<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;"> </font>
</p>
<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;font-weight:bold;">4. Available-for-Sale Securities and Fair Value Measurements</font>
</p>
<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;"> </font>
</p>
<p style="margin:0pt;text-indent:36pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">Our available-for-sale securities include:</font>
</p>
<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;"> </font>
</p>
<div style="width:100%;"><table cellpadding="0" cellspacing="0" style="border-collapse:collapse;width: 93.00%;margin-left:18pt;">
<tr>
<td valign="bottom" style="width:49.00%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 8pt;">
<font style="display:inline;font-size:8pt;"> </font></p>
</td>
<td valign="bottom" style="width:02.68%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td valign="bottom" style="width:14.00%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman,Times,serif;font-size: 8pt;">
<font style="display:inline;font-weight:bold;font-size:8pt;">Fair Value</font></p>
</td>
<td valign="bottom" style="width:02.68%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td colspan="2" valign="bottom" style="width:14.00%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td valign="bottom" style="width:02.68%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td colspan="2" valign="bottom" style="width:14.00%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td valign="bottom" style="width:00.98%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
</tr>
<tr>
<td valign="bottom" style="width:49.00%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 8pt;">
<font style="display:inline;font-size:8pt;"> </font></p>
</td>
<td valign="bottom" style="width:02.68%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td valign="bottom" style="width:14.00%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman,Times,serif;font-size: 8pt;">
<font style="display:inline;font-weight:bold;font-size:8pt;">Hierarchy</font></p>
</td>
<td valign="bottom" style="width:02.68%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td colspan="5" valign="bottom" style="width:30.68%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman,Times,serif;font-size: 8pt;">
<font style="display:inline;font-weight:bold;font-size:8pt;">Estimated Fair Value</font></p>
</td>
<td valign="bottom" style="width:00.98%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
</tr>
<tr>
<td valign="bottom" style="width:49.00%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 8pt;">
<font style="display:inline;font-weight:bold;font-size:8pt;">(In thousands)</font></p>
</td>
<td valign="bottom" style="width:02.68%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td valign="bottom" style="width:14.00%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman,Times,serif;font-size: 8pt;">
<font style="display:inline;font-weight:bold;font-size:8pt;">Level</font></p>
</td>
<td valign="bottom" style="width:02.68%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td colspan="2" valign="bottom" style="width:14.00%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman,Times,serif;font-size: 8pt;">
<font style="display:inline;font-weight:bold;font-size:8pt;">March 31, 2016</font></p>
</td>
<td valign="bottom" style="width:02.68%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td colspan="2" valign="bottom" style="width:14.00%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman,Times,serif;font-size: 8pt;">
<font style="display:inline;font-weight:bold;font-size:8pt;">December 31, 2015</font></p>
</td>
<td valign="bottom" style="width:00.98%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
</tr>
<tr>
<td valign="top" style="width:49.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10.1pt;line-height:106.67%;text-indent: -10.1pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">U.S. government securities</font></p>
</td>
<td valign="bottom" style="width:02.68%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td valign="bottom" style="width:14.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">Level 1</font></p>
</td>
<td valign="bottom" style="width:02.68%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td valign="bottom" style="width:01.20%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">$</font></p>
</td>
<td valign="bottom" style="width:12.80%;background-color: #CCEEFF;;font-family:Times New Roman,Times,serif;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>42,150
</td>
<td valign="bottom" style="width:02.68%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td valign="bottom" style="width:01.20%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">$</font></p>
</td>
<td valign="bottom" style="width:12.80%;background-color: #CCEEFF;;font-family:Times New Roman,Times,serif;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>47,043
</td>
<td valign="bottom" style="width:00.98%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
</tr>
<tr>
<td valign="top" style="width:49.00%;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10.1pt;line-height:106.67%;text-indent: -10.1pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">U.S. government agency securities</font></p>
</td>
<td valign="bottom" style="width:02.68%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td valign="bottom" style="width:14.00%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">Level 2</font></p>
</td>
<td valign="bottom" style="width:02.68%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td colspan="2" valign="bottom" style="width:14.00%;;font-family:Times New Roman,Times,serif;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>26,014
</td>
<td valign="bottom" style="width:02.68%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td colspan="2" valign="bottom" style="width:14.00%;;font-family:Times New Roman,Times,serif;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>31,465
</td>
<td valign="bottom" style="width:00.98%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
</tr>
<tr>
<td valign="top" style="width:49.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10.1pt;line-height:106.67%;text-indent: -10.1pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">Corporate notes</font></p>
</td>
<td valign="bottom" style="width:02.68%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td valign="bottom" style="width:14.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">Level 2</font></p>
</td>
<td valign="bottom" style="width:02.68%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td colspan="2" valign="bottom" style="width:14.00%;background-color: #CCEEFF;;font-family:Times New Roman,Times,serif;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>12,511
</td>
<td valign="bottom" style="width:02.68%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td colspan="2" valign="bottom" style="width:14.00%;background-color: #CCEEFF;;font-family:Times New Roman,Times,serif;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>19,089
</td>
<td valign="bottom" style="width:00.98%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
</tr>
<tr>
<td valign="top" style="width:49.00%;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10.1pt;line-height:106.67%;text-indent: -10.1pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">Commerial paper</font></p>
</td>
<td valign="bottom" style="width:02.68%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td valign="bottom" style="width:14.00%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">Level 2</font></p>
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<td valign="bottom" style="width:02.68%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td colspan="2" valign="bottom" style="width:14.00%;;font-family:Times New Roman,Times,serif;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>4,996
</td>
<td valign="bottom" style="width:02.68%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td colspan="2" valign="bottom" style="width:14.00%;;font-family:Times New Roman,Times,serif;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>4,990
</td>
<td valign="bottom" style="width:00.98%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
</tr>
<tr>
<td valign="top" style="width:49.00%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td valign="bottom" style="width:02.68%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td valign="bottom" style="width:14.00%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td valign="bottom" style="width:02.68%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td colspan="2" valign="bottom" style="width:14.00%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td valign="bottom" style="width:02.68%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td colspan="2" valign="bottom" style="width:14.00%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td valign="bottom" style="width:00.98%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
</tr>
<tr>
<td valign="top" style="width:49.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt 0pt 0pt 20.2pt;line-height:106.67%;text-indent: -10.1pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">Marketable securities</font></p>
</td>
<td valign="bottom" style="width:02.68%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td valign="bottom" style="width:14.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td valign="bottom" style="width:02.68%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td colspan="2" valign="bottom" style="width:14.00%;background-color: #CCEEFF;;font-family:Times New Roman,Times,serif;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>85,671
</td>
<td valign="bottom" style="width:02.68%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td colspan="2" valign="bottom" style="width:14.00%;background-color: #CCEEFF;;font-family:Times New Roman,Times,serif;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>102,587
</td>
<td valign="bottom" style="width:00.98%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
</tr>
<tr>
<td valign="top" style="width:49.00%;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10.1pt;line-height:106.67%;text-indent: -10.1pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">Money market funds</font></p>
</td>
<td valign="bottom" style="width:02.68%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td valign="bottom" style="width:14.00%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">Level 1</font></p>
</td>
<td valign="bottom" style="width:02.68%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td colspan="2" valign="bottom" style="width:14.00%;;font-family:Times New Roman,Times,serif;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>75,514
</td>
<td valign="bottom" style="width:02.68%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td colspan="2" valign="bottom" style="width:14.00%;;font-family:Times New Roman,Times,serif;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>69,126
</td>
<td valign="bottom" style="width:00.98%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
</tr>
<tr>
<td valign="top" style="width:49.00%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td valign="bottom" style="width:02.68%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td valign="bottom" style="width:14.00%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td valign="bottom" style="width:02.68%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td colspan="2" valign="bottom" style="width:14.00%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td valign="bottom" style="width:02.68%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td colspan="2" valign="bottom" style="width:14.00%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td valign="bottom" style="width:00.98%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
</tr>
<tr>
<td valign="top" style="width:49.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt 0pt 0pt 20.2pt;line-height:106.67%;text-indent: -10.1pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">Total</font></p>
</td>
<td valign="bottom" style="width:02.68%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td valign="bottom" style="width:14.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td valign="bottom" style="width:02.68%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td valign="bottom" style="width:01.20%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">$</font></p>
</td>
<td valign="bottom" style="width:12.80%;background-color: #CCEEFF;;font-family:Times New Roman,Times,serif;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>161,185
</td>
<td valign="bottom" style="width:02.68%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td valign="bottom" style="width:01.20%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">$</font></p>
</td>
<td valign="bottom" style="width:12.78%;background-color: #CCEEFF;;font-family:Times New Roman,Times,serif;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>171,713
</td>
<td valign="bottom" style="width:00.98%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
</tr>
<tr>
<td valign="top" style="width:49.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td valign="bottom" style="width:02.68%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td valign="bottom" style="width:14.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td valign="bottom" style="width:02.68%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td valign="bottom" style="width:01.20%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:2pt double #000000 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td valign="bottom" style="width:12.80%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:2pt double #000000 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td valign="bottom" style="width:02.68%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td valign="bottom" style="width:01.20%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:2pt double #000000 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td valign="bottom" style="width:12.78%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:2pt double #000000 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td valign="bottom" style="width:00.98%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
</tr>
</table></div>
<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;"> </font>
</p>
<p style="margin:0pt;text-indent:36pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">The estimated fair value of marketable securities is based on quoted market prices for these or similar investments that were based on prices obtained from a commercial pricing service. The fair value of our marketable securities classified within Level 2 is based upon observable inputs that may include benchmark yields, reported trades, broker/dealer quotes, issuer spreads, two-sided markets, benchmark securities, bids, offers and reference data including market research publications. Gross unrealized gains and losses were not significant at either March 31, 2016 or December 31, 2015.</font>
</p>
<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;"> </font>
</p>
<p style="margin:0pt;text-indent:36pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">At March 31, 2016, all of the marketable securities had contractual maturities within two years and the weighted average maturity of the marketable securities was approximately nine months. There were no transfers between Level 1 and Level 2 during the periods presented and there have been no changes to our valuation techniques during the three months ended March 31, 2016.</font>
</p>
<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;"> </font>
</p>
<p style="margin:0pt;text-indent:36pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">We do not intend to sell the investments that are in an unrealized loss position, and it is unlikely that we will be required to sell the investments before recovery of their amortized cost basis, which may be maturity. We have determined that the gross unrealized losses on our marketable securities at March 31, 2016 were temporary in nature. All marketable securities with unrealized losses at March 31, 2016 have been in a loss position for less than twelve months.</font>
</p>
<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;"> </font>
</p>
<p style="margin:0pt;punctuation-wrap:hanging;text-indent:36pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">At March 31, 2016, our accumulated other comprehensive income (loss) on our condensed consolidated balance sheets consisted of net unrealized gains on available-for-sale investments. During the three months ended March 31, 2016, we did not sell any of our marketable securities. Restricted cash pertained to certain lease agreements and letters of credit where we have pledged cash and cash equivalents as collateral.</font>
</p>
<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;"> </font>
</p></div><div style="margin-left:0%;margin-right:0%;">
<p><font size="1"> </font></p></div><div style="margin-left:0%;margin-right:0%;"></div> </div>
19200000
4554000
422000
4132000
0
32372000
1185000
31173000
14000
<div> <div style="margin-left:0%;margin-right:0%;"></div><div style="margin-left:0%;margin-right:0%;">
<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="font-size: 10pt;font-family:Times New Roman,Times,serif;text-indent:0pt;margin-left:0pt;padding:0pt 36pt 0pt 0pt;"></font><font style="display:inline;"></font><font style="display:inline;;font-size: 10pt;font-family:Times New Roman,Times,serif;text-indent:0pt;margin-left:0pt;padding:0pt 36pt 0pt 0pt;"></font><font style="display:inline;"></font><font style="display:inline;;font-size: 10pt;font-family:Times New Roman,Times,serif;text-indent:0pt;margin-left:0pt;padding:0pt 36pt 0pt 0pt;"></font><font style="display:inline;"></font><font style="display:inline;;font-size: 10pt;font-family:Times New Roman,Times,serif;text-indent:0pt;margin-left:0pt;padding:0pt 36pt 0pt 0pt;"></font><font style="display:inline;"></font><font style="display:inline;;font-size: 10pt;font-family:Times New Roman,Times,serif;text-indent:0pt;margin-left:0pt;padding:0pt 36pt 0pt 0pt;"></font><font style="display:inline;"></font><font style="display:inline;;font-size: 10pt;font-family:Times New Roman,Times,serif;text-indent:0pt;margin-left:0pt;padding:0pt 36pt 0pt 0pt;"></font><font style="display:inline;"></font><font style="display:inline;;font-size: 10pt;font-family:Times New Roman,Times,serif;text-indent:0pt;margin-left:0pt;padding:0pt 36pt 0pt 0pt;"></font><font style="display:inline;"></font><font style="display:inline;;font-size: 10pt;font-family:Times New Roman,Times,serif;text-indent:0pt;margin-left:0pt;padding:0pt 36pt 0pt 0pt;"></font><font style="display:inline;"></font><font style="display:inline;;font-size: 10pt;font-family:Times New Roman,Times,serif;text-indent:0pt;margin-left:0pt;padding:0pt 36pt 0pt 0pt;"></font><font style="display:inline;"></font><font style="display:inline;;font-size: 10pt;font-family:Times New Roman,Times,serif;text-indent:0pt;margin-left:0pt;padding:0pt 36pt 0pt 0pt;"></font><font style="display:inline;"></font><font style="display:inline;;font-size: 10pt;font-family:Times New Roman,Times,serif;text-indent:0pt;margin-left:0pt;padding:0pt 36pt 0pt 0pt;"></font><font style="display:inline;"></font><font style="display:inline;;font-size: 10pt;font-family:Times New Roman,Times,serif;text-indent:0pt;margin-left:0pt;padding:0pt 36pt 0pt 0pt;"></font><font style="display:inline;"></font><font style="display:inline;;font-size: 10pt;font-family:Times New Roman,Times,serif;text-indent:0pt;margin-left:0pt;padding:0pt 36pt 0pt 0pt;"></font><font style="display:inline;"></font><font style="display:inline;;font-size: 10pt;font-family:Times New Roman,Times,serif;text-indent:0pt;margin-left:0pt;padding:0pt 36pt 0pt 0pt;"></font><font style="display:inline;"></font><font style="display:inline;;font-size: 10pt;font-family:Times New Roman,Times,serif;text-indent:0pt;margin-left:0pt;padding:0pt 36pt 0pt 0pt;"></font><font style="display:inline;"></font><font style="display:inline;;font-size: 10pt;font-family:Times New Roman,Times,serif;text-indent:0pt;margin-left:0pt;padding:0pt 36pt 0pt 0pt;"></font><font style="display:inline;"></font><font style="display:inline;;font-size: 10pt;font-family:Times New Roman,Times,serif;text-indent:0pt;margin-left:0pt;padding:0pt 36pt 0pt 0pt;"></font><font style="display:inline;"></font><font style="display:inline;"></font>
</p>
<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;"> </font>
</p>
<div style="width:100%;"><table cellpadding="0" cellspacing="0" style="border-collapse:collapse;width: 100.00%;margin-left:0pt;">
<tr>
<td valign="bottom" style="width:70.00%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 8pt;">
<font style="display:inline;font-size:8pt;"> </font></p>
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td colspan="5" valign="bottom" style="width:26.50%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman,Times,serif;font-size: 8pt;">
<font style="display:inline;font-weight:bold;font-size:8pt;">Three Months Ended March 31,</font></p>
</td>
<td valign="bottom" style="width:01.00%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
</tr>
<tr>
<td valign="bottom" style="width:70.00%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 8pt;">
<font style="display:inline;font-weight:bold;font-size:8pt;">(In thousands)</font></p>
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td colspan="2" valign="bottom" style="width:12.00%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman,Times,serif;font-size: 8pt;">
<font style="display:inline;font-weight:bold;font-size:8pt;">2016</font></p>
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td colspan="2" valign="bottom" style="width:12.00%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman,Times,serif;font-size: 8pt;">
<font style="display:inline;font-weight:bold;font-size:8pt;">2015</font></p>
</td>
<td valign="bottom" style="width:01.00%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
</tr>
<tr>
<td valign="top" style="width:70.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10.1pt;line-height:106.67%;text-indent: -10.1pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">Mylan</font></p>
</td>
<td valign="bottom" style="width:02.50%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td valign="bottom" style="width:01.12%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">$</font></p>
</td>
<td valign="bottom" style="width:10.88%;background-color: #CCEEFF;;font-family:Times New Roman,Times,serif;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>15,025
</td>
<td valign="bottom" style="width:02.50%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td valign="bottom" style="width:01.12%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">$</font></p>
</td>
<td valign="bottom" style="width:10.88%;background-color: #CCEEFF;;font-family:Times New Roman,Times,serif;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>19,099
</td>
<td valign="bottom" style="width:01.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
</tr>
<tr>
<td valign="top" style="width:70.00%;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10.1pt;line-height:106.67%;text-indent: -10.1pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">Other</font></p>
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td colspan="2" valign="bottom" style="width:12.00%;;font-family:Times New Roman,Times,serif;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>74
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td colspan="2" valign="bottom" style="width:12.00%;;font-family:Times New Roman,Times,serif;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>22
</td>
<td valign="bottom" style="width:01.00%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
</tr>
<tr>
<td valign="top" style="width:70.00%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td colspan="2" valign="bottom" style="width:12.00%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td colspan="2" valign="bottom" style="width:12.00%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td valign="bottom" style="width:01.00%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
</tr>
<tr>
<td valign="top" style="width:70.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt 0pt 0pt 20.2pt;line-height:106.67%;text-indent: -10.1pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">Total revenue from collaborative arrangements</font></p>
</td>
<td valign="bottom" style="width:02.50%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td valign="bottom" style="width:01.12%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">$</font></p>
</td>
<td valign="bottom" style="width:10.88%;background-color: #CCEEFF;;font-family:Times New Roman,Times,serif;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>15,099
</td>
<td valign="bottom" style="width:02.50%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td valign="bottom" style="width:01.12%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">$</font></p>
</td>
<td valign="bottom" style="width:10.86%;background-color: #CCEEFF;;font-family:Times New Roman,Times,serif;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>19,121
</td>
<td valign="bottom" style="width:01.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
</tr>
<tr>
<td valign="top" style="width:70.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td valign="bottom" style="width:02.50%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td valign="bottom" style="width:01.12%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:2pt double #000000 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td valign="bottom" style="width:10.88%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:2pt double #000000 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td valign="bottom" style="width:02.50%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td valign="bottom" style="width:01.12%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:2pt double #000000 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td valign="bottom" style="width:10.86%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:2pt double #000000 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td valign="bottom" style="width:01.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
</tr>
</table></div>
<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;"> </font>
</p></div><div style="margin-left:0%;margin-right:0%;">
<p><font size="1"> </font></p></div><div style="margin-left:0%;margin-right:0%;"></div> </div>
19121000
19099000
22000
15099000
15025000
74000
17820000
2304000
15000000
171713000
161185000
P2Y
P9M
69126000
75514000
0.233
0.50
23000000
35232000
37536000
4200000
0.030
<div> <div style="margin-left:0%;margin-right:0%;"></div><div style="margin-left:0%;margin-right:0%;">
<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;"> </font>
</p>
<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;font-weight:bold;font-style:italic;">Significant Accounting Policies</font>
</p>
<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;"> </font>
</p>
<p style="margin:0pt;text-indent:36pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">There have been no material revisions in our significant accounting policies described in Note 1 to the consolidated financial statements included in our Annual Report on Form 10-K for the year ended December 31, 2015.</font>
</p>
<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;"> </font>
</p></div><div style="margin-left:0%;margin-right:0%;">
<p><font size="1"> </font></p></div><div style="margin-left:0%;margin-right:0%;"></div> </div>
18804000
9092000
1922000
1527000
-70000
126000
564691000
602117000
15626000
7482000
8144000
11330000
5160000
6170000
0
26700000
11400000
15300000
758000
894000
4748000
4353000
395000
5633000
4136000
1497000
300116000
293125000
237472000
238752000
102587000
47043000
4990000
19089000
31465000
85671000
42150000
4996000
12511000
26014000
59727000
51073000
42860000
34598000
<div> <div style="margin-left:0%;margin-right:0%;"></div><div style="margin-left:0%;margin-right:0%;">
<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="font-size: 10pt;font-family:Times New Roman,Times,serif;text-indent:0pt;margin-left:0pt;padding:0pt 36pt 0pt 0pt;"></font><font style="display:inline;"></font><font style="display:inline;;font-size: 10pt;font-family:Times New Roman,Times,serif;text-indent:0pt;margin-left:0pt;padding:0pt 36pt 0pt 0pt;"></font><font style="display:inline;"></font><font style="display:inline;;font-size: 10pt;font-family:Times New Roman,Times,serif;text-indent:0pt;margin-left:0pt;padding:0pt 36pt 0pt 0pt;"></font><font style="display:inline;"></font><font style="display:inline;;font-size: 10pt;font-family:Times New Roman,Times,serif;text-indent:0pt;margin-left:0pt;padding:0pt 36pt 0pt 0pt;"></font><font style="display:inline;"></font><font style="display:inline;;font-size: 10pt;font-family:Times New Roman,Times,serif;text-indent:0pt;margin-left:0pt;padding:0pt 36pt 0pt 0pt;"></font><font style="display:inline;"></font><font style="display:inline;;font-size: 10pt;font-family:Times New Roman,Times,serif;text-indent:0pt;margin-left:0pt;padding:0pt 36pt 0pt 0pt;"></font><font style="display:inline;"></font><font style="display:inline;;font-size: 10pt;font-family:Times New Roman,Times,serif;text-indent:0pt;margin-left:0pt;padding:0pt 36pt 0pt 0pt;"></font><font style="display:inline;"></font><font style="display:inline;;font-size: 10pt;font-family:Times New Roman,Times,serif;text-indent:0pt;margin-left:0pt;padding:0pt 36pt 0pt 0pt;"></font><font style="display:inline;"></font><font style="display:inline;;font-size: 10pt;font-family:Times New Roman,Times,serif;text-indent:0pt;margin-left:0pt;padding:0pt 36pt 0pt 0pt;"></font><font style="display:inline;"></font><font style="display:inline;;font-size: 10pt;font-family:Times New Roman,Times,serif;text-indent:0pt;margin-left:0pt;padding:0pt 36pt 0pt 0pt;"></font><font style="display:inline;"></font><font style="display:inline;;font-size: 10pt;font-family:Times New Roman,Times,serif;text-indent:0pt;margin-left:0pt;padding:0pt 36pt 0pt 0pt;"></font><font style="display:inline;"></font><font style="display:inline;;font-size: 10pt;font-family:Times New Roman,Times,serif;text-indent:0pt;margin-left:0pt;padding:0pt 36pt 0pt 0pt;"></font><font style="display:inline;"></font><font style="display:inline;;font-size: 10pt;font-family:Times New Roman,Times,serif;text-indent:0pt;margin-left:0pt;padding:0pt 36pt 0pt 0pt;"></font><font style="display:inline;"></font><font style="display:inline;;font-size: 10pt;font-family:Times New Roman,Times,serif;text-indent:0pt;margin-left:0pt;padding:0pt 36pt 0pt 0pt;"></font><font style="display:inline;"></font><font style="display:inline;;font-size: 10pt;font-family:Times New Roman,Times,serif;text-indent:0pt;margin-left:0pt;padding:0pt 36pt 0pt 0pt;"></font><font style="display:inline;"></font><font style="display:inline;;font-size: 10pt;font-family:Times New Roman,Times,serif;text-indent:0pt;margin-left:0pt;padding:0pt 36pt 0pt 0pt;"></font><font style="display:inline;"></font><font style="display:inline;;font-size: 10pt;font-family:Times New Roman,Times,serif;text-indent:0pt;margin-left:0pt;padding:0pt 36pt 0pt 0pt;"></font><font style="display:inline;"></font><font style="display:inline;"></font>
</p>
<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;"> </font>
</p>
<div style="width:100%;"><table cellpadding="0" cellspacing="0" style="border-collapse:collapse;width: 93.00%;margin-left:18pt;">
<tr>
<td valign="bottom" style="width:49.00%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 8pt;">
<font style="display:inline;font-size:8pt;"> </font></p>
</td>
<td valign="bottom" style="width:02.68%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td valign="bottom" style="width:14.00%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman,Times,serif;font-size: 8pt;">
<font style="display:inline;font-weight:bold;font-size:8pt;">Fair Value</font></p>
</td>
<td valign="bottom" style="width:02.68%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td colspan="2" valign="bottom" style="width:14.00%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td valign="bottom" style="width:02.68%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td colspan="2" valign="bottom" style="width:14.00%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td valign="bottom" style="width:00.98%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
</tr>
<tr>
<td valign="bottom" style="width:49.00%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 8pt;">
<font style="display:inline;font-size:8pt;"> </font></p>
</td>
<td valign="bottom" style="width:02.68%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td valign="bottom" style="width:14.00%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman,Times,serif;font-size: 8pt;">
<font style="display:inline;font-weight:bold;font-size:8pt;">Hierarchy</font></p>
</td>
<td valign="bottom" style="width:02.68%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td colspan="5" valign="bottom" style="width:30.68%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman,Times,serif;font-size: 8pt;">
<font style="display:inline;font-weight:bold;font-size:8pt;">Estimated Fair Value</font></p>
</td>
<td valign="bottom" style="width:00.98%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
</tr>
<tr>
<td valign="bottom" style="width:49.00%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 8pt;">
<font style="display:inline;font-weight:bold;font-size:8pt;">(In thousands)</font></p>
</td>
<td valign="bottom" style="width:02.68%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td valign="bottom" style="width:14.00%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman,Times,serif;font-size: 8pt;">
<font style="display:inline;font-weight:bold;font-size:8pt;">Level</font></p>
</td>
<td valign="bottom" style="width:02.68%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td colspan="2" valign="bottom" style="width:14.00%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman,Times,serif;font-size: 8pt;">
<font style="display:inline;font-weight:bold;font-size:8pt;">March 31, 2016</font></p>
</td>
<td valign="bottom" style="width:02.68%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td colspan="2" valign="bottom" style="width:14.00%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman,Times,serif;font-size: 8pt;">
<font style="display:inline;font-weight:bold;font-size:8pt;">December 31, 2015</font></p>
</td>
<td valign="bottom" style="width:00.98%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
</tr>
<tr>
<td valign="top" style="width:49.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10.1pt;line-height:106.67%;text-indent: -10.1pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">U.S. government securities</font></p>
</td>
<td valign="bottom" style="width:02.68%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td valign="bottom" style="width:14.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">Level 1</font></p>
</td>
<td valign="bottom" style="width:02.68%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td valign="bottom" style="width:01.20%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">$</font></p>
</td>
<td valign="bottom" style="width:12.80%;background-color: #CCEEFF;;font-family:Times New Roman,Times,serif;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>42,150
</td>
<td valign="bottom" style="width:02.68%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td valign="bottom" style="width:01.20%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">$</font></p>
</td>
<td valign="bottom" style="width:12.80%;background-color: #CCEEFF;;font-family:Times New Roman,Times,serif;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>47,043
</td>
<td valign="bottom" style="width:00.98%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
</tr>
<tr>
<td valign="top" style="width:49.00%;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10.1pt;line-height:106.67%;text-indent: -10.1pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">U.S. government agency securities</font></p>
</td>
<td valign="bottom" style="width:02.68%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td valign="bottom" style="width:14.00%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">Level 2</font></p>
</td>
<td valign="bottom" style="width:02.68%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td colspan="2" valign="bottom" style="width:14.00%;;font-family:Times New Roman,Times,serif;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>26,014
</td>
<td valign="bottom" style="width:02.68%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td colspan="2" valign="bottom" style="width:14.00%;;font-family:Times New Roman,Times,serif;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>31,465
</td>
<td valign="bottom" style="width:00.98%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
</tr>
<tr>
<td valign="top" style="width:49.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10.1pt;line-height:106.67%;text-indent: -10.1pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">Corporate notes</font></p>
</td>
<td valign="bottom" style="width:02.68%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td valign="bottom" style="width:14.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">Level 2</font></p>
</td>
<td valign="bottom" style="width:02.68%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td colspan="2" valign="bottom" style="width:14.00%;background-color: #CCEEFF;;font-family:Times New Roman,Times,serif;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>12,511
</td>
<td valign="bottom" style="width:02.68%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td colspan="2" valign="bottom" style="width:14.00%;background-color: #CCEEFF;;font-family:Times New Roman,Times,serif;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>19,089
</td>
<td valign="bottom" style="width:00.98%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
</tr>
<tr>
<td valign="top" style="width:49.00%;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10.1pt;line-height:106.67%;text-indent: -10.1pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">Commerial paper</font></p>
</td>
<td valign="bottom" style="width:02.68%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td valign="bottom" style="width:14.00%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">Level 2</font></p>
</td>
<td valign="bottom" style="width:02.68%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td colspan="2" valign="bottom" style="width:14.00%;;font-family:Times New Roman,Times,serif;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>4,996
</td>
<td valign="bottom" style="width:02.68%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td colspan="2" valign="bottom" style="width:14.00%;;font-family:Times New Roman,Times,serif;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>4,990
</td>
<td valign="bottom" style="width:00.98%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
</tr>
<tr>
<td valign="top" style="width:49.00%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td valign="bottom" style="width:02.68%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td valign="bottom" style="width:14.00%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td valign="bottom" style="width:02.68%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td colspan="2" valign="bottom" style="width:14.00%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td valign="bottom" style="width:02.68%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td colspan="2" valign="bottom" style="width:14.00%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td valign="bottom" style="width:00.98%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
</tr>
<tr>
<td valign="top" style="width:49.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt 0pt 0pt 20.2pt;line-height:106.67%;text-indent: -10.1pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">Marketable securities</font></p>
</td>
<td valign="bottom" style="width:02.68%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td valign="bottom" style="width:14.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td valign="bottom" style="width:02.68%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td colspan="2" valign="bottom" style="width:14.00%;background-color: #CCEEFF;;font-family:Times New Roman,Times,serif;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>85,671
</td>
<td valign="bottom" style="width:02.68%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td colspan="2" valign="bottom" style="width:14.00%;background-color: #CCEEFF;;font-family:Times New Roman,Times,serif;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>102,587
</td>
<td valign="bottom" style="width:00.98%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
</tr>
<tr>
<td valign="top" style="width:49.00%;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10.1pt;line-height:106.67%;text-indent: -10.1pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">Money market funds</font></p>
</td>
<td valign="bottom" style="width:02.68%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td valign="bottom" style="width:14.00%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">Level 1</font></p>
</td>
<td valign="bottom" style="width:02.68%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td colspan="2" valign="bottom" style="width:14.00%;;font-family:Times New Roman,Times,serif;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>75,514
</td>
<td valign="bottom" style="width:02.68%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td colspan="2" valign="bottom" style="width:14.00%;;font-family:Times New Roman,Times,serif;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>69,126
</td>
<td valign="bottom" style="width:00.98%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
</tr>
<tr>
<td valign="top" style="width:49.00%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td valign="bottom" style="width:02.68%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td valign="bottom" style="width:14.00%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td valign="bottom" style="width:02.68%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td colspan="2" valign="bottom" style="width:14.00%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td valign="bottom" style="width:02.68%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td colspan="2" valign="bottom" style="width:14.00%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td valign="bottom" style="width:00.98%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
</tr>
<tr>
<td valign="top" style="width:49.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt 0pt 0pt 20.2pt;line-height:106.67%;text-indent: -10.1pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">Total</font></p>
</td>
<td valign="bottom" style="width:02.68%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td valign="bottom" style="width:14.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td valign="bottom" style="width:02.68%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td valign="bottom" style="width:01.20%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">$</font></p>
</td>
<td valign="bottom" style="width:12.80%;background-color: #CCEEFF;;font-family:Times New Roman,Times,serif;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>161,185
</td>
<td valign="bottom" style="width:02.68%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td valign="bottom" style="width:01.20%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">$</font></p>
</td>
<td valign="bottom" style="width:12.78%;background-color: #CCEEFF;;font-family:Times New Roman,Times,serif;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>171,713
</td>
<td valign="bottom" style="width:00.98%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
</tr>
<tr>
<td valign="top" style="width:49.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td valign="bottom" style="width:02.68%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td valign="bottom" style="width:14.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td valign="bottom" style="width:02.68%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td valign="bottom" style="width:01.20%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:2pt double #000000 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td valign="bottom" style="width:12.80%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:2pt double #000000 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td valign="bottom" style="width:02.68%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td valign="bottom" style="width:01.20%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:2pt double #000000 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td valign="bottom" style="width:12.78%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:2pt double #000000 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td valign="bottom" style="width:00.98%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
</tr>
</table></div>
<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;"> </font>
</p></div><div style="margin-left:0%;margin-right:0%;">
<p><font size="1"> </font></p></div><div style="margin-left:0%;margin-right:0%;"></div> </div>
<div> <div style="margin-left:0%;margin-right:0%;"></div><div style="margin-left:0%;margin-right:0%;">
<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;"> </font>
</p>
<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;font-weight:bold;font-style:italic;">Basis of Presentation</font>
</p>
<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;"> </font>
</p>
<p style="margin:0pt;text-indent:36pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">The Company’s condensed</font><font style="display:inline;"> consolidated financial information as of March 31, 2016, and the three months ended March 31, 2016 and 2015 are unaudited but include all adjustments (consisting only of normal recurring adjustments), which we consider necessary for a fair presentation of the financial position at such date and of the operating results and cash flows for those periods, and have been prepared in accordance with U.S. generally accepted accounting principles (“GAAP”) for interim financial information. Accordingly, they do not include all of the information and notes required by GAAP for complete financial statements. The accompanying unaudited condensed consolidated financial statements should be read in conjunction with the audited consolidated December 31, 2015 financial statements and notes thereto included in our Annual Report on Form 10-K for the year ended December 31, 2015, filed with the Securities and Exchange Commission (“SEC”) on March 11, 2016.</font>
</p>
<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;"> </font>
</p></div><div style="margin-left:0%;margin-right:0%;">
<p><font size="1"> </font></p></div><div style="margin-left:0%;margin-right:0%;"></div> </div>
89215000
100899000
112707000
128803000
<div> <div style="margin-left:0%;margin-right:0%;"></div><div style="margin-left:0%;margin-right:0%;">
<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;"> </font>
</p>
<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;font-weight:bold;">3. Collaborative Arrangements</font>
</p>
<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;"> </font>
</p>
<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;font-weight:bold;font-style:italic;">Revenue from Collaborative Arrangements</font>
</p>
<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;"> </font>
</p>
<p style="margin:0pt;text-indent:36pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">We recognized the following revenues from our collaborative arrangements:</font>
</p>
<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;"> </font>
</p>
<div style="width:100%;"><table cellpadding="0" cellspacing="0" style="border-collapse:collapse;width: 100.00%;margin-left:0pt;">
<tr>
<td valign="bottom" style="width:70.00%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 8pt;">
<font style="display:inline;font-size:8pt;"> </font></p>
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td colspan="5" valign="bottom" style="width:26.50%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman,Times,serif;font-size: 8pt;">
<font style="display:inline;font-weight:bold;font-size:8pt;">Three Months Ended March 31,</font></p>
</td>
<td valign="bottom" style="width:01.00%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
</tr>
<tr>
<td valign="bottom" style="width:70.00%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 8pt;">
<font style="display:inline;font-weight:bold;font-size:8pt;">(In thousands)</font></p>
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td colspan="2" valign="bottom" style="width:12.00%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman,Times,serif;font-size: 8pt;">
<font style="display:inline;font-weight:bold;font-size:8pt;">2016</font></p>
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td colspan="2" valign="bottom" style="width:12.00%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman,Times,serif;font-size: 8pt;">
<font style="display:inline;font-weight:bold;font-size:8pt;">2015</font></p>
</td>
<td valign="bottom" style="width:01.00%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
</tr>
<tr>
<td valign="top" style="width:70.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10.1pt;line-height:106.67%;text-indent: -10.1pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">Mylan</font></p>
</td>
<td valign="bottom" style="width:02.50%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td valign="bottom" style="width:01.12%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">$</font></p>
</td>
<td valign="bottom" style="width:10.88%;background-color: #CCEEFF;;font-family:Times New Roman,Times,serif;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>15,025
</td>
<td valign="bottom" style="width:02.50%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td valign="bottom" style="width:01.12%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">$</font></p>
</td>
<td valign="bottom" style="width:10.88%;background-color: #CCEEFF;;font-family:Times New Roman,Times,serif;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>19,099
</td>
<td valign="bottom" style="width:01.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
</tr>
<tr>
<td valign="top" style="width:70.00%;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10.1pt;line-height:106.67%;text-indent: -10.1pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">Other</font></p>
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td colspan="2" valign="bottom" style="width:12.00%;;font-family:Times New Roman,Times,serif;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>74
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td colspan="2" valign="bottom" style="width:12.00%;;font-family:Times New Roman,Times,serif;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>22
</td>
<td valign="bottom" style="width:01.00%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
</tr>
<tr>
<td valign="top" style="width:70.00%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td colspan="2" valign="bottom" style="width:12.00%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td colspan="2" valign="bottom" style="width:12.00%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td valign="bottom" style="width:01.00%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
</tr>
<tr>
<td valign="top" style="width:70.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt 0pt 0pt 20.2pt;line-height:106.67%;text-indent: -10.1pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">Total revenue from collaborative arrangements</font></p>
</td>
<td valign="bottom" style="width:02.50%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td valign="bottom" style="width:01.12%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">$</font></p>
</td>
<td valign="bottom" style="width:10.88%;background-color: #CCEEFF;;font-family:Times New Roman,Times,serif;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>15,099
</td>
<td valign="bottom" style="width:02.50%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td valign="bottom" style="width:01.12%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">$</font></p>
</td>
<td valign="bottom" style="width:10.86%;background-color: #CCEEFF;;font-family:Times New Roman,Times,serif;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>19,121
</td>
<td valign="bottom" style="width:01.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
</tr>
<tr>
<td valign="top" style="width:70.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td valign="bottom" style="width:02.50%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td valign="bottom" style="width:01.12%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:2pt double #000000 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td valign="bottom" style="width:10.88%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:2pt double #000000 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td valign="bottom" style="width:02.50%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td valign="bottom" style="width:01.12%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:2pt double #000000 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td valign="bottom" style="width:10.86%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:2pt double #000000 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td valign="bottom" style="width:01.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
</tr>
</table></div>
<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;"> </font>
</p>
<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;font-weight:bold;font-style:italic;">Mylan</font>
</p>
<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;"> </font>
</p>
<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;font-style:italic;">Development and Commercialization Agreement</font>
</p>
<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;"> </font>
</p>
<p style="margin:0pt;text-indent:36pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">In January 2015, we established a strategic collaboration with Mylan Ireland Limited (“Mylan”) for the development and, subject to regulatory approval, commercialization of revefenacin (TD-4208), our investigational LAMA in development for the treatment of COPD. We entered into this collaboration to expand the breadth of our revefenacin development program and extend our commercial reach beyond the acute care setting where we currently market VIBATIV.</font>
</p>
<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;"> </font>
</p>
<p style="margin:0pt;text-indent:36pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">In the first quarter of 2015, upfront payments totaling $19.2 million from Mylan were allocated to the license and committee participation deliverables based on the relative selling price method. The $19.2 million consisted of the initial payment of $15.0 million in cash and the $4.2 million premium related to the equity investment, which represents the difference between the closing price on January 30, 2015 and the issued price of $18.918 per share. For the three months ended March 31, 2015, we recognized $19.1 million in revenue from the Mylan collaborative arrangement related primarily to the license and technological know-how delivered in the first quarter of 2015.</font>
</p>
<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;"> </font>
</p>
<p style="margin:0pt;text-indent:36pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">For the three months ended March 31, 2016, we recognized $15.0 million in revenue from the Mylan collaborative arrangement for the achievement of 50% enrollment in the Phase 3 twelve-month safety study, which triggered a milestone payment to Theravance Biopharma by Mylan.</font>
</p>
<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;"> </font>
</p>
<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;font-weight:bold;font-style:italic;">Reimbursement of R&D Costs</font>
</p>
<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;"> </font>
</p>
<p style="margin:0pt;text-indent:36pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">Under certain collaborative arrangements, we are entitled to reimbursement of certain R&D costs. Our policy is to account for the reimbursement payments by our collaboration partners as reductions to R&D expense.</font>
</p>
<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;"> </font>
</p>
<p style="margin:0pt;text-indent:36pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">The following table summarizes the reductions to R&D expenses related to the reimbursement payments:</font>
</p>
<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;"> </font>
</p>
<div style="width:100%;"><table cellpadding="0" cellspacing="0" style="border-collapse:collapse;width: 100.00%;margin-left:0pt;">
<tr>
<td valign="bottom" style="width:70.00%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 8pt;">
<font style="display:inline;font-size:8pt;"> </font></p>
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td colspan="5" valign="bottom" style="width:26.50%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman,Times,serif;font-size: 8pt;">
<font style="display:inline;font-weight:bold;font-size:8pt;">Three Months Ended March 31,</font></p>
</td>
<td valign="bottom" style="width:01.00%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
</tr>
<tr>
<td valign="bottom" style="width:70.00%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 8pt;">
<font style="display:inline;font-weight:bold;font-size:8pt;">(In thousands)</font></p>
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td colspan="2" valign="bottom" style="width:12.00%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman,Times,serif;font-size: 8pt;">
<font style="display:inline;font-weight:bold;font-size:8pt;">2016</font></p>
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td colspan="2" valign="bottom" style="width:12.00%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman,Times,serif;font-size: 8pt;">
<font style="display:inline;font-weight:bold;font-size:8pt;">2015</font></p>
</td>
<td valign="bottom" style="width:01.00%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
</tr>
<tr>
<td valign="top" style="width:70.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10.1pt;line-height:106.67%;text-indent: -10.1pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">Mylan</font></p>
</td>
<td valign="bottom" style="width:02.50%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td valign="bottom" style="width:01.12%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">$</font></p>
</td>
<td valign="bottom" style="width:10.88%;background-color: #CCEEFF;;font-family:Times New Roman,Times,serif;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>31,173
</td>
<td valign="bottom" style="width:02.50%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td valign="bottom" style="width:01.12%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">$</font></p>
</td>
<td valign="bottom" style="width:10.88%;background-color: #CCEEFF;;font-family:Times New Roman,Times,serif;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>4,132
</td>
<td valign="bottom" style="width:01.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
</tr>
<tr>
<td valign="top" style="width:70.00%;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10.1pt;line-height:106.67%;text-indent: -10.1pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">Alfa Wassermann</font></p>
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td colspan="2" valign="bottom" style="width:12.00%;;font-family:Times New Roman,Times,serif;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>1,185
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td colspan="2" valign="bottom" style="width:12.00%;;font-family:Times New Roman,Times,serif;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>422
</td>
<td valign="bottom" style="width:01.00%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
</tr>
<tr>
<td valign="top" style="width:70.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10.1pt;line-height:106.67%;text-indent: -10.1pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">R-Pharm</font></p>
</td>
<td valign="bottom" style="width:02.50%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td colspan="2" valign="bottom" style="width:12.00%;background-color: #CCEEFF;;font-family:Times New Roman,Times,serif;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>14
</td>
<td valign="bottom" style="width:02.50%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td colspan="2" valign="bottom" style="width:12.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:right;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">—</font></p>
</td>
<td valign="bottom" style="width:01.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
</tr>
<tr>
<td valign="top" style="width:70.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td valign="bottom" style="width:02.50%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td colspan="2" valign="bottom" style="width:12.00%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td valign="bottom" style="width:02.50%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td colspan="2" valign="bottom" style="width:12.00%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td valign="bottom" style="width:01.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
</tr>
<tr>
<td valign="top" style="width:70.00%;padding:0pt;">
<p style="margin:0pt 0pt 0pt 20.2pt;line-height:106.67%;text-indent: -10.1pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">Total reduction to R&D costs</font></p>
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td valign="bottom" style="width:01.12%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">$</font></p>
</td>
<td valign="bottom" style="width:10.88%;;font-family:Times New Roman,Times,serif;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>32,372
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td valign="bottom" style="width:01.12%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">$</font></p>
</td>
<td valign="bottom" style="width:10.86%;;font-family:Times New Roman,Times,serif;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>4,554
</td>
<td valign="bottom" style="width:01.00%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
</tr>
<tr>
<td valign="top" style="width:70.00%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td valign="bottom" style="width:01.12%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:2pt double #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td valign="bottom" style="width:10.88%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:2pt double #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td valign="bottom" style="width:01.12%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:2pt double #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td valign="bottom" style="width:10.86%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:2pt double #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td valign="bottom" style="width:01.00%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
</tr>
</table></div>
<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;"> </font>
</p></div><div style="margin-left:0%;margin-right:0%;">
<p><font size="1"> </font></p></div><div style="margin-left:0%;margin-right:0%;"></div> </div>
<div> <div style="margin-left:0%;margin-right:0%;"></div><div style="margin-left:0%;margin-right:0%;">
<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;"> </font>
</p>
<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;font-weight:bold;">9. Commitments and Contingencies</font>
</p>
<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;"> </font>
</p>
<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;font-weight:bold;font-style:italic;">Guarantees and Indemnifications</font>
</p>
<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;"> </font>
</p>
<p style="margin:0pt;text-indent:36pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">We indemnify our officers and directors for certain events or occurrences, subject to certain limits. We believe the fair value of these indemnification agreements is minimal. Accordingly, we have not recognized any liabilities relating to these agreements as of March 31, 2016.</font>
</p>
<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;"> </font>
</p></div><div style="margin-left:0%;margin-right:0%;">
<p><font size="1"> </font></p></div><div style="margin-left:0%;margin-right:0%;"></div> </div>
0.00001
0.00001
0.00001
200000000
200000000
37981000
41452000
37981000
41452000
-42361000
-41954000
371000
778000
4598000
4449000
144000
1120000
0
825000
699000
<div> <div style="margin-left:0%;margin-right:0%;"></div><div style="margin-left:0%;margin-right:0%;">
<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;"> </font>
</p>
<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;font-weight:bold;">6. Share-Based Compensation</font>
</p>
<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;"> </font>
</p>
<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;font-weight:bold;font-style:italic;">Share-Based Compensation Expense Allocation</font>
</p>
<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;"> </font>
</p>
<p style="margin:0pt;text-indent:36pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">The allocation of share-based compensation expense included in the condensed consolidated statements of operations was as follows:</font>
</p>
<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;"> </font>
</p>
<div style="width:100%;"><table cellpadding="0" cellspacing="0" style="border-collapse:collapse;width: 100.00%;margin-left:0pt;">
<tr>
<td valign="bottom" style="width:70.00%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 8pt;">
<font style="display:inline;font-size:8pt;"> </font></p>
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td colspan="5" valign="bottom" style="width:26.50%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman,Times,serif;font-size: 8pt;">
<font style="display:inline;font-weight:bold;font-size:8pt;">Three Months Ended March 31,</font></p>
</td>
<td valign="bottom" style="width:01.00%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
</tr>
<tr>
<td valign="bottom" style="width:70.00%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 8pt;">
<font style="display:inline;font-weight:bold;font-size:8pt;">(In thousands)</font></p>
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td colspan="2" valign="bottom" style="width:12.00%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman,Times,serif;font-size: 8pt;">
<font style="display:inline;font-weight:bold;font-size:8pt;">2016</font></p>
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td colspan="2" valign="bottom" style="width:12.00%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman,Times,serif;font-size: 8pt;">
<font style="display:inline;font-weight:bold;font-size:8pt;">2015</font></p>
</td>
<td valign="bottom" style="width:01.00%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
</tr>
<tr>
<td valign="top" style="width:70.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10.1pt;line-height:106.67%;text-indent: -10.1pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">Research and development</font></p>
</td>
<td valign="bottom" style="width:02.50%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td valign="bottom" style="width:01.12%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">$</font></p>
</td>
<td valign="bottom" style="width:10.88%;background-color: #CCEEFF;;font-family:Times New Roman,Times,serif;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>5,160
</td>
<td valign="bottom" style="width:02.50%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td valign="bottom" style="width:01.12%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">$</font></p>
</td>
<td valign="bottom" style="width:10.88%;background-color: #CCEEFF;;font-family:Times New Roman,Times,serif;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>7,482
</td>
<td valign="bottom" style="width:01.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
</tr>
<tr>
<td valign="top" style="width:70.00%;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10.1pt;line-height:106.67%;text-indent: -10.1pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">Selling, general and administrative</font></p>
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td colspan="2" valign="bottom" style="width:12.00%;;font-family:Times New Roman,Times,serif;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>6,170
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td colspan="2" valign="bottom" style="width:12.00%;;font-family:Times New Roman,Times,serif;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>8,144
</td>
<td valign="bottom" style="width:01.00%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
</tr>
<tr>
<td valign="top" style="width:70.00%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td colspan="2" valign="bottom" style="width:12.00%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td colspan="2" valign="bottom" style="width:12.00%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td valign="bottom" style="width:01.00%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
</tr>
<tr>
<td valign="top" style="width:70.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt 0pt 0pt 20.2pt;line-height:106.67%;text-indent: -10.1pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">Total share-based compensation expense</font></p>
</td>
<td valign="bottom" style="width:02.50%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td valign="bottom" style="width:01.12%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">$</font></p>
</td>
<td valign="bottom" style="width:10.88%;background-color: #CCEEFF;;font-family:Times New Roman,Times,serif;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>11,330
</td>
<td valign="bottom" style="width:02.50%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td valign="bottom" style="width:01.12%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">$</font></p>
</td>
<td valign="bottom" style="width:10.86%;background-color: #CCEEFF;;font-family:Times New Roman,Times,serif;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>15,626
</td>
<td valign="bottom" style="width:01.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
</tr>
<tr>
<td valign="top" style="width:70.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td valign="bottom" style="width:02.50%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td valign="bottom" style="width:01.12%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:2pt double #000000 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td valign="bottom" style="width:10.88%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:2pt double #000000 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td valign="bottom" style="width:02.50%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td valign="bottom" style="width:01.12%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:2pt double #000000 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td valign="bottom" style="width:10.86%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:2pt double #000000 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td valign="bottom" style="width:01.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
</tr>
</table></div>
<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;"> </font>
</p>
<p style="margin:0pt;text-indent:36pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">Total share-based compensation expense capitalized to inventory was not material for any of the periods presented.</font>
</p>
<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;"> </font>
</p>
<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;font-weight:bold;font-style:italic;">Performance-Contingent Awards</font>
</p>
<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;"> </font>
</p>
<p style="margin:0pt;text-indent:36pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">In the first quarter of 2016, the Compensation Committee of the Company’s Board of Directors approved the grant of 1,575,000 performance-contingent restricted stock awards (RSAs) and 135,000 performance-contingent restricted share units (RSUs) to senior management. These grants have dual triggers of vesting based upon the achievement of certain performance conditions over a five-year timeframe from 2016 to 2020 and continued employment, both of which must be satisfied in order for the awards to vest.</font>
</p>
<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;"> </font>
</p>
<p style="margin:0pt;text-indent:36pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">Expense associated with these awards would be recognized during the years 2016 to 2020 depending on the probability of meeting the performance conditions. The maximum potential expense associated with the awards could be up to approximately $26.7 million (allocated as $11.4 million for research and development expense and $15.3 million for selling, general and administrative expense) if all of the performance conditions are achieved on time. Compensation expense relating to awards subject to performance conditions is recognized if it is considered probable that the performance goals will be achieved. The probability of achievement will be reassessed each reporting period. As of March 31, 2016, we determined that the achievement of the requisite performance conditions was not probable and, as a result, no compensation expense related to these awards has been recognized.</font>
</p>
<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;"> </font>
</p></div><div style="margin-left:0%;margin-right:0%;">
<p><font size="1"> </font></p></div><div style="margin-left:0%;margin-right:0%;"></div> </div>
-1.29
-1.10
<div> <div style="margin-left:0%;margin-right:0%;"></div><div style="margin-left:0%;margin-right:0%;">
<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;"> </font>
</p>
<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;font-weight:bold;">2. Net Loss per Share</font>
</p>
<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;"> </font>
</p>
<p style="margin:0pt;text-indent:36pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">Basic net loss per share is computed by dividing net loss by the weighted-average number of shares outstanding, less ordinary shares subject to forfeiture. Diluted net loss per share is computed by dividing net loss by the weighted-average number of shares outstanding, less ordinary shares subject to forfeiture, plus all additional ordinary shares that would have been outstanding, assuming dilutive potential common shares had been issued for other dilutive securities.</font>
</p>
<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;"> </font>
</p>
<p style="margin:0pt;text-indent:36pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">For the three months ended March 31, 2016 and 2015, diluted and basic net loss per share was identical since potential common shares were excluded from the calculation, as their effect was anti-dilutive.</font>
</p>
<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;"> </font>
</p>
<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;font-weight:bold;font-style:italic;">Anti-Dilutive Securities</font>
</p>
<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;"> </font>
</p>
<p style="margin:0pt;text-indent:36pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">The following common equivalent shares were not included in the computation of diluted net loss per share because their effect was anti-dilutive:</font>
</p>
<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;"> </font>
</p>
<div style="width:100%;"><table cellpadding="0" cellspacing="0" style="border-collapse:collapse;width: 100.00%;margin-left:0pt;">
<tr>
<td valign="bottom" style="width:70.00%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 8pt;">
<font style="display:inline;font-size:8pt;"> </font></p>
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td colspan="3" valign="bottom" style="width:26.50%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman,Times,serif;font-size: 8pt;">
<font style="display:inline;font-weight:bold;font-size:8pt;">Three Months Ended March 31,</font></p>
</td>
<td valign="bottom" style="width:01.00%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
</tr>
<tr>
<td valign="bottom" style="width:70.00%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 8pt;">
<font style="display:inline;font-weight:bold;font-size:8pt;">(In thousands)</font></p>
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td valign="bottom" style="width:12.00%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman,Times,serif;font-size: 8pt;">
<font style="display:inline;font-weight:bold;font-size:8pt;">2016</font></p>
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td valign="bottom" style="width:12.00%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman,Times,serif;font-size: 8pt;">
<font style="display:inline;font-weight:bold;font-size:8pt;">2015</font></p>
</td>
<td valign="bottom" style="width:01.00%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
</tr>
<tr>
<td valign="top" style="width:70.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10.1pt;line-height:106.67%;text-indent: -10.1pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">Share issuances under equity incentive plan and ESPP</font></p>
</td>
<td valign="bottom" style="width:02.50%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td valign="bottom" style="width:12.00%;background-color: #CCEEFF;;font-family:Times New Roman,Times,serif;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>4,136
</td>
<td valign="bottom" style="width:02.50%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td valign="bottom" style="width:12.00%;background-color: #CCEEFF;;font-family:Times New Roman,Times,serif;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>4,353
</td>
<td valign="bottom" style="width:01.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
</tr>
<tr>
<td valign="top" style="width:70.00%;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10.1pt;line-height:106.67%;text-indent: -10.1pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">Restricted shares</font></p>
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td valign="bottom" style="width:12.00%;;font-family:Times New Roman,Times,serif;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>1,497
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td valign="bottom" style="width:12.00%;;font-family:Times New Roman,Times,serif;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>395
</td>
<td valign="bottom" style="width:01.00%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
</tr>
<tr>
<td valign="top" style="width:70.00%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td valign="bottom" style="width:12.00%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td valign="bottom" style="width:12.00%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td valign="bottom" style="width:01.00%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
</tr>
<tr>
<td valign="top" style="width:70.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10.1pt;line-height:106.67%;text-indent: -10.1pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;"> </font></p>
</td>
<td valign="bottom" style="width:02.50%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td valign="bottom" style="width:12.00%;background-color: #CCEEFF;;font-family:Times New Roman,Times,serif;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>5,633
</td>
<td valign="bottom" style="width:02.50%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td valign="bottom" style="width:12.00%;background-color: #CCEEFF;;font-family:Times New Roman,Times,serif;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>4,748
</td>
<td valign="bottom" style="width:01.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
</tr>
<tr>
<td valign="top" style="width:70.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td valign="bottom" style="width:02.50%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td valign="bottom" style="width:12.00%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:2pt double #000000 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td valign="bottom" style="width:02.50%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td valign="bottom" style="width:12.00%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:2pt double #000000 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td valign="bottom" style="width:01.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
</tr>
</table></div>
<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;"> </font>
</p></div><div style="margin-left:0%;margin-right:0%;">
<p><font size="1"> </font></p></div><div style="margin-left:0%;margin-right:0%;"></div> </div>
10866000
7824000
391000
0
391000
0
0
0
0
0
-37526000
-41456000
<div> <div style="margin-left:0%;margin-right:0%;"></div><div style="margin-left:0%;margin-right:0%;">
<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;"> </font>
</p>
<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;font-weight:bold;">7. Income Taxes</font>
</p>
<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;"> </font>
</p>
<p style="margin:0pt;text-indent:36pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">The income tax provision was $0.7 million for the three months ended March 31, 2016. The provision for income tax was primarily due to uncertain tax positions taken with respect to transfer pricing and tax credits. No provision for income taxes has been recognized on undistributed earnings of our foreign subsidiaries because we consider such earnings to be indefinitely reinvested.</font>
</p>
<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;"> </font>
</p>
<p style="margin:0pt;text-indent:36pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">We follow the accounting guidance related to accounting for income taxes which requires that a company reduce its deferred tax assets by a valuation allowance if, based on the weight of available evidence, it is more likely than not that some portion or all of its deferred tax assets will not be realized. At March 31, 2016, our deferred tax assets were offset in full by a valuation allowance.</font>
</p>
<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;"> </font>
</p>
<p style="margin:0pt;text-indent:36pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">We record liabilities related to uncertain tax positions in accordance with the income tax guidance which clarifies the accounting for uncertainty in income taxes recognized in an enterprise’s financial statements by prescribing a minimum recognition threshold and measurement attribute for the financial statement recognition and measurement of a tax position taken or expected to be taken in a tax return. Resolution of one or more of these uncertain tax positions in any period may have a material impact on the results of operations for that period. We include any applicable interest and penalties within the provision for income taxes in the condensed consolidated statements of operations.</font>
</p>
<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;"> </font>
</p>
<p style="margin:0pt;text-indent:36pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">The difference between the Irish statutory rate and our effective tax rate is primarily due to the valuation allowance on deferred tax assets and the liabilities recorded for the uncertain tax position related to transfer pricing and tax credits.</font>
</p>
<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;"> </font>
</p>
<p style="margin:0pt;text-indent:36pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">Our future income tax expense may be affected by such factors as changes in tax laws, our business, regulations, tax rates, interpretation of existing laws or regulations, the impact of accounting for share-based compensation, the impact of accounting for business combinations, our international organization, shifts in the amount of income before tax earned in the U.S. as compared with other regions in the world, and changes in overall levels of income before tax.</font>
</p>
<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;"> </font>
</p></div><div style="margin-left:0%;margin-right:0%;">
<p><font size="1"> </font></p></div><div style="margin-left:0%;margin-right:0%;"></div> </div>
765000
9494000
4948000
694000
-5431000
-9450000
276000
-395000
-6184000
5718000
106000
149000
212000
1141000
41000
-134000
321000
590000
180000
-255000
664000
5050000
10000
-12522000
<div> <div style="margin-left:0%;margin-right:0%;"></div><div style="margin-left:0%;margin-right:0%;">
<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;"> </font>
</p>
<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;font-weight:bold;">5. Inventories</font>
</p>
<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;"> </font>
</p>
<p style="margin:0pt;text-indent:36pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">Inventory consists of the following:</font>
</p>
<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;;font-size: 10pt;font-family:Times New Roman,Times,serif;text-indent:0pt;margin-left:0pt;padding:0pt 36pt 0pt 0pt;"></font><font style="display:inline;"></font><font style="display:inline;;font-size: 10pt;font-family:Times New Roman,Times,serif;text-indent:0pt;margin-left:0pt;padding:0pt 36pt 0pt 0pt;"></font><font style="display:inline;"></font><font style="display:inline;;font-size: 10pt;font-family:Times New Roman,Times,serif;text-indent:0pt;margin-left:0pt;padding:0pt 36pt 0pt 0pt;"></font><font style="display:inline;"></font><font style="display:inline;;font-size: 10pt;font-family:Times New Roman,Times,serif;text-indent:0pt;margin-left:0pt;padding:0pt 36pt 0pt 0pt;"></font><font style="display:inline;"></font><font style="display:inline;;font-size: 10pt;font-family:Times New Roman,Times,serif;text-indent:0pt;margin-left:0pt;padding:0pt 36pt 0pt 0pt;"></font><font style="display:inline;"></font><font style="display:inline;;font-size: 10pt;font-family:Times New Roman,Times,serif;text-indent:0pt;margin-left:0pt;padding:0pt 36pt 0pt 0pt;"></font><font style="display:inline;"></font><font style="display:inline;;font-size: 10pt;font-family:Times New Roman,Times,serif;text-indent:0pt;margin-left:0pt;padding:0pt 36pt 0pt 0pt;"></font><font style="display:inline;"></font><font style="display:inline;;font-size: 10pt;font-family:Times New Roman,Times,serif;text-indent:0pt;margin-left:0pt;padding:0pt 36pt 0pt 0pt;"></font><font style="display:inline;"></font><font style="display:inline;;font-size: 10pt;font-family:Times New Roman,Times,serif;text-indent:0pt;margin-left:0pt;padding:0pt 36pt 0pt 0pt;"></font><font style="display:inline;"></font><font style="display:inline;;font-size: 10pt;font-family:Times New Roman,Times,serif;text-indent:0pt;margin-left:0pt;padding:0pt 36pt 0pt 0pt;"></font><font style="display:inline;"></font><font style="display:inline;;font-size: 10pt;font-family:Times New Roman,Times,serif;text-indent:0pt;margin-left:0pt;padding:0pt 36pt 0pt 0pt;"></font><font style="display:inline;"></font><font style="display:inline;;font-size: 10pt;font-family:Times New Roman,Times,serif;text-indent:0pt;margin-left:0pt;padding:0pt 36pt 0pt 0pt;"></font><font style="display:inline;"></font><font style="display:inline;;font-size: 10pt;font-family:Times New Roman,Times,serif;text-indent:0pt;margin-left:0pt;padding:0pt 36pt 0pt 0pt;"></font><font style="display:inline;"></font><font style="display:inline;;font-size: 10pt;font-family:Times New Roman,Times,serif;text-indent:0pt;margin-left:0pt;padding:0pt 36pt 0pt 0pt;"></font><font style="display:inline;"></font><font style="display:inline;;font-size: 10pt;font-family:Times New Roman,Times,serif;text-indent:0pt;margin-left:0pt;padding:0pt 36pt 0pt 0pt;"></font><font style="display:inline;"></font><font style="display:inline;;font-size: 10pt;font-family:Times New Roman,Times,serif;text-indent:0pt;margin-left:0pt;padding:0pt 36pt 0pt 0pt;"></font><font style="display:inline;"></font><font style="display:inline;;font-size: 10pt;font-family:Times New Roman,Times,serif;text-indent:0pt;margin-left:0pt;padding:0pt 36pt 0pt 0pt;"></font><font style="display:inline;"></font><font style="display:inline;"></font>
</p>
<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;"> </font>
</p>
<div style="width:100%;"><table cellpadding="0" cellspacing="0" style="border-collapse:collapse;width: 100.00%;margin-left:0pt;">
<tr>
<td valign="bottom" style="width:70.00%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 8pt;">
<font style="display:inline;font-weight:bold;font-size:8pt;">(In thousands)</font></p>
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td colspan="2" valign="bottom" style="width:12.00%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman,Times,serif;font-size: 8pt;">
<font style="display:inline;font-weight:bold;font-size:8pt;">March 31,</font><br /><font style="display:inline;font-weight:bold;font-size:8pt;">2016</font></p>
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td colspan="2" valign="bottom" style="width:12.00%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman,Times,serif;font-size: 8pt;">
<font style="display:inline;font-weight:bold;font-size:8pt;">December 31,</font><br /><font style="display:inline;font-weight:bold;font-size:8pt;">2015</font></p>
</td>
<td valign="bottom" style="width:01.00%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
</tr>
<tr>
<td valign="top" style="width:70.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10.1pt;line-height:106.67%;text-indent: -10.1pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">Raw materials</font></p>
</td>
<td valign="bottom" style="width:02.50%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td valign="bottom" style="width:01.12%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">$</font></p>
</td>
<td valign="bottom" style="width:10.88%;background-color: #CCEEFF;;font-family:Times New Roman,Times,serif;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>5,270
</td>
<td valign="bottom" style="width:02.50%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td valign="bottom" style="width:01.12%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">$</font></p>
</td>
<td valign="bottom" style="width:10.88%;background-color: #CCEEFF;;font-family:Times New Roman,Times,serif;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>6,869
</td>
<td valign="bottom" style="width:01.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
</tr>
<tr>
<td valign="top" style="width:70.00%;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10.1pt;line-height:106.67%;text-indent: -10.1pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">Work-in-process</font></p>
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td colspan="2" valign="bottom" style="width:12.00%;;font-family:Times New Roman,Times,serif;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>1,758
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td colspan="2" valign="bottom" style="width:12.00%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:right;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">—</font></p>
</td>
<td valign="bottom" style="width:01.00%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
</tr>
<tr>
<td valign="top" style="width:70.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10.1pt;line-height:106.67%;text-indent: -10.1pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">Finished goods</font></p>
</td>
<td valign="bottom" style="width:02.50%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td colspan="2" valign="bottom" style="width:12.00%;background-color: #CCEEFF;;font-family:Times New Roman,Times,serif;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>2,378
</td>
<td valign="bottom" style="width:02.50%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td colspan="2" valign="bottom" style="width:12.00%;background-color: #CCEEFF;;font-family:Times New Roman,Times,serif;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>3,136
</td>
<td valign="bottom" style="width:01.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
</tr>
<tr>
<td valign="top" style="width:70.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td valign="bottom" style="width:02.50%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td colspan="2" valign="bottom" style="width:12.00%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td valign="bottom" style="width:02.50%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td colspan="2" valign="bottom" style="width:12.00%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td valign="bottom" style="width:01.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
</tr>
<tr>
<td valign="top" style="width:70.00%;padding:0pt;">
<p style="margin:0pt 0pt 0pt 20.2pt;line-height:106.67%;text-indent: -10.1pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">Total inventories</font></p>
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td valign="bottom" style="width:01.12%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">$</font></p>
</td>
<td valign="bottom" style="width:10.88%;;font-family:Times New Roman,Times,serif;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>9,406
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td valign="bottom" style="width:01.12%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">$</font></p>
</td>
<td valign="bottom" style="width:10.88%;;font-family:Times New Roman,Times,serif;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>10,005
</td>
<td valign="bottom" style="width:01.00%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
</tr>
<tr>
<td valign="top" style="width:70.00%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td valign="bottom" style="width:01.12%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:2pt double #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td valign="bottom" style="width:10.88%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:2pt double #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td valign="bottom" style="width:01.12%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:2pt double #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td valign="bottom" style="width:10.88%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:2pt double #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td valign="bottom" style="width:01.00%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
</tr>
</table></div>
<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;"> </font>
</p></div><div style="margin-left:0%;margin-right:0%;">
<p><font size="1"> </font></p></div><div style="margin-left:0%;margin-right:0%;"></div> </div>
3136000
2378000
10005000
9406000
6869000
5270000
0
1758000
79000
10000
300116000
293125000
49470000
46401000
11684000
16096000
26044000
26020000
42154000
16385000
-56514000
-26309000
-42474000
-42150000
<div> <div style="margin-left:0%;margin-right:0%;"></div><div style="margin-left:0%;margin-right:0%;">
<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;"> </font>
</p>
<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;font-weight:bold;font-style:italic;">Recently Issued Accounting Pronouncements Not Yet Adopted</font>
</p>
<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;"> </font>
</p>
<p style="margin:0pt;text-indent:36pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">In February 2016, the FASB issued Accounting Standards Update No. 2016-02,</font><font style="display:inline;font-style:italic;"> Leases</font><font style="display:inline;"> (“ASU 2016-02”)</font><font style="display:inline;">.</font><font style="display:inline;font-style:italic;"> </font><font style="display:inline;">ASU 2016-02 is aimed at making leasing activities more transparent and comparable, and requires substantially all leases be recognized by lessees on their balance sheet as a right-of-use asset and corresponding lease liability, including leases currently accounted for as operating leases. ASU 2016-02 is effective for all interim and annual reporting periods beginning after December 15, 2018 with early adoption permitted. We are currently evaluating the impact that the adoption of ASU 2016-02 will have on our consolidated financial statements and related disclosures.</font>
</p>
<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;"> </font>
</p>
<p style="margin:0pt;text-indent:36pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">In March 2016, the FASB issued Accounting Standards Update No. 2016-08,</font><font style="display:inline;font-style:italic;"> Revenue from Contracts with Customers (Topic 606)</font><font style="display:inline;"> (“ASU 2016-08”) which clarifies whether an entity is a principal or an agent in a transaction in which another party in involved in providing goods or services to a customer. ASU 2016-08 also clarifies (i) how an entity should identify the unit of accounting for the principal versus agent evaluation and (ii) how the control principle applies to transactions, and reframes the indicators to focus on evidence that an entity is acting as a principal rather than as an agent. ASU 2016-08 is effective for all interim and annual reporting periods beginning after December 15, 2017, and early adoption is permitted for interim and annual reporting periods beginning after December 15, 2016. </font><font style="display:inline;">We are currently evaluating the impact that the adoption of ASU 2016-08 will have on our consolidated financial statements and related disclosures.</font>
</p>
<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;"> </font>
</p>
<p style="margin:0pt;text-indent:36pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">In March 2016, the FASB also issued Accounting Standards Update No. 2016-09, </font><font style="display:inline;font-style:italic;">Compensation — Stock Compensation (Topic 718)</font><font style="display:inline;"> (“ASU 2016-09”). ASU 2016-09 simplifies several aspects of the accounting for share-based payment transactions, including the income tax consequences, classification of awards as equity or liabilities, an option to recognize gross share compensation expense with actual forfeitures recognized as they occur, as well as certain classifications on the statement of cash flows. ASU 2016-09 is effective for all interim and annual reporting periods beginning after December 15, 2016 with early adoption permitted. We are currently evaluating the potential impact that the adoption of ASU 2016-09 will have on our consolidated financial statements and related disclosures.</font>
</p></div><div style="margin-left:0%;margin-right:0%;">
<p><font size="1"> </font></p></div><div style="margin-left:0%;margin-right:0%;"></div> </div>
58138000
60052000
-37737000
-41642000
<div> <div style="margin-left:0%;margin-right:0%;"></div><div style="margin-left:0%;margin-right:0%;">
<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;"> </font>
</p>
<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;font-weight:bold;">1. Description of Operations and Summary of Significant Accounting Policies</font>
</p>
<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;"> </font>
</p>
<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;font-weight:bold;font-style:italic;">Description of Operations</font>
</p>
<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;"> </font>
</p>
<p style="margin:0pt;text-indent:36pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">Theravance Biopharma, Inc. (“Theravance Biopharma”, the “Company”, or “we” and other similar pronouns) is a diversified biopharmaceutical company with the core purpose of creating medicines that make a difference in the lives of patients suffering from serious illness.</font>
</p>
<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;"> </font>
</p>
<p style="margin:0pt;text-indent:36pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">Our pipeline of internally discovered product candidates includes potential best-in-class medicines to address the unmet needs of patients being treated for serious conditions primarily in the acute care setting. VIBATIV</font><font style="display:inline;font-size:6.5pt;">®</font><font style="display:inline;"> (telavancin), our first commercial product, is a once-daily dual-mechanism antibiotic approved in the U.S., Europe and certain other countries for certain difficult-to-treat infections. Revefenacin (TD-4208) is a long-acting muscarinic antagonist (“LAMA”) being developed as a potential once-daily, nebulized treatment for chronic obstructive pulmonary disease (“COPD”). Our neprilysin (“NEP”) inhibitor program is designed to develop selective NEP inhibitors for the treatment of a range of major cardiovascular and renal diseases, including acute and chronic heart failure, hypertension and chronic kidney diseases such as diabetic nephropathy. Our research efforts are focused in the areas of inflammation and immunology, with the goal of designing medicines that provide targeted drug delivery to tissues in the lung and gastrointestinal tract in order to maximize patient benefit and minimize risk. The first program to emerge from this research is designed to develop GI-targeted pan-Janus kinases (“JAK”) inhibitors for the treatment of a range of inflammatory intestinal diseases.</font>
</p>
<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;"> </font>
</p>
<p style="margin:0pt;text-indent:36pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">In addition, we have an economic interest in future payments that may be made by Glaxo Group Limited or one of its affiliates (“GSK”) pursuant to its agreements with Innoviva, Inc. (“Innoviva”) (known as Theravance, Inc. prior to January 7, 2016) relating to certain drug development programs, including the Closed Triple (the combination of fluticasone furoate, umeclidinium, and vilanterol), currently in development for the treatment of COPD and asthma.</font>
</p>
<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;"> </font>
</p>
<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;font-weight:bold;font-style:italic;">Basis of Presentation</font>
</p>
<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;"> </font>
</p>
<p style="margin:0pt;text-indent:36pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">The Company’s condensed</font><font style="display:inline;"> consolidated financial information as of March 31, 2016, and the three months ended March 31, 2016 and 2015 are unaudited but include all adjustments (consisting only of normal recurring adjustments), which we consider necessary for a fair presentation of the financial position at such date and of the operating results and cash flows for those periods, and have been prepared in accordance with U.S. generally accepted accounting principles (“GAAP”) for interim financial information. Accordingly, they do not include all of the information and notes required by GAAP for complete financial statements. The accompanying unaudited condensed consolidated financial statements should be read in conjunction with the audited consolidated December 31, 2015 financial statements and notes thereto included in our Annual Report on Form 10-K for the year ended December 31, 2015, filed with the Securities and Exchange Commission (“SEC”) on March 11, 2016.</font>
</p>
<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;"> </font>
</p>
<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;font-weight:bold;font-style:italic;">Significant Accounting Policies</font>
</p>
<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;"> </font>
</p>
<p style="margin:0pt;text-indent:36pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">There have been no material revisions in our significant accounting policies described in Note 1 to the consolidated financial statements included in our Annual Report on Form 10-K for the year ended December 31, 2015.</font>
</p>
<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;"> </font>
</p>
<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;font-weight:bold;font-style:italic;">Recently Issued Accounting Pronouncements Not Yet Adopted</font>
</p>
<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;"> </font>
</p>
<p style="margin:0pt;text-indent:36pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">In February 2016, the FASB issued Accounting Standards Update No. 2016-02,</font><font style="display:inline;font-style:italic;"> Leases</font><font style="display:inline;"> (“ASU 2016-02”)</font><font style="display:inline;">.</font><font style="display:inline;font-style:italic;"> </font><font style="display:inline;">ASU 2016-02 is aimed at making leasing activities more transparent and comparable, and requires substantially all leases be recognized by lessees on their balance sheet as a right-of-use asset and corresponding lease liability, including leases currently accounted for as operating leases. ASU 2016-02 is effective for all interim and annual reporting periods beginning after December 15, 2018 with early adoption permitted. We are currently evaluating the impact that the adoption of ASU 2016-02 will have on our consolidated financial statements and related disclosures.</font>
</p>
<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;"> </font>
</p>
<p style="margin:0pt;text-indent:36pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">In March 2016, the FASB issued Accounting Standards Update No. 2016-08,</font><font style="display:inline;font-style:italic;"> Revenue from Contracts with Customers (Topic 606)</font><font style="display:inline;"> (“ASU 2016-08”) which clarifies whether an entity is a principal or an agent in a transaction in which another party in involved in providing goods or services to a customer. ASU 2016-08 also clarifies (i) how an entity should identify the unit of accounting for the principal versus agent evaluation and (ii) how the control principle applies to transactions, and reframes the indicators to focus on evidence that an entity is acting as a principal rather than as an agent. ASU 2016-08 is effective for all interim and annual reporting periods beginning after December 15, 2017, and early adoption is permitted for interim and annual reporting periods beginning after December 15, 2016. </font><font style="display:inline;">We are currently evaluating the impact that the adoption of ASU 2016-08 will have on our consolidated financial statements and related disclosures.</font>
</p>
<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;"> </font>
</p>
<p style="margin:0pt;text-indent:36pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">In March 2016, the FASB also issued Accounting Standards Update No. 2016-09, </font><font style="display:inline;font-style:italic;">Compensation — Stock Compensation (Topic 718)</font><font style="display:inline;"> (“ASU 2016-09”). ASU 2016-09 simplifies several aspects of the accounting for share-based payment transactions, including the income tax consequences, classification of awards as equity or liabilities, an option to recognize gross share compensation expense with actual forfeitures recognized as they occur, as well as certain classifications on the statement of cash flows. ASU 2016-09 is effective for all interim and annual reporting periods beginning after December 15, 2016 with early adoption permitted. We are currently evaluating the potential impact that the adoption of ASU 2016-09 will have on our consolidated financial statements and related disclosures.</font>
</p>
<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;"> </font>
</p></div><div style="margin-left:0%;margin-right:0%;">
<p><font size="1"> </font></p></div><div style="margin-left:0%;margin-right:0%;"></div> </div>
4947000
4725000
1078000
823000
113000
196000
2983000
3738000
8000000
8000000
211000
186000
5115000
10165000
100000
1782000
10659000
0
657000
684000
0.00001
0.00001
230000
230000
0
0
0
0
12764000
242000
25753000
50000000
27802000
5000000
14600000
107700000
53470000
17069000
9873000
10119000
<div> <div style="margin-left:0%;margin-right:0%;"></div><div style="margin-left:0%;margin-right:0%;">
<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="font-size: 10pt;font-family:Times New Roman,Times,serif;text-indent:0pt;margin-left:0pt;padding:0pt 36pt 0pt 0pt;"></font><font style="display:inline;"></font><font style="display:inline;;font-size: 10pt;font-family:Times New Roman,Times,serif;text-indent:0pt;margin-left:0pt;padding:0pt 36pt 0pt 0pt;"></font><font style="display:inline;"></font><font style="display:inline;;font-size: 10pt;font-family:Times New Roman,Times,serif;text-indent:0pt;margin-left:0pt;padding:0pt 36pt 0pt 0pt;"></font><font style="display:inline;"></font><font style="display:inline;;font-size: 10pt;font-family:Times New Roman,Times,serif;text-indent:0pt;margin-left:0pt;padding:0pt 36pt 0pt 0pt;"></font><font style="display:inline;"></font><font style="display:inline;;font-size: 10pt;font-family:Times New Roman,Times,serif;text-indent:0pt;margin-left:0pt;padding:0pt 36pt 0pt 0pt;"></font><font style="display:inline;"></font><font style="display:inline;;font-size: 10pt;font-family:Times New Roman,Times,serif;text-indent:0pt;margin-left:0pt;padding:0pt 36pt 0pt 0pt;"></font><font style="display:inline;"></font><font style="display:inline;;font-size: 10pt;font-family:Times New Roman,Times,serif;text-indent:0pt;margin-left:0pt;padding:0pt 36pt 0pt 0pt;"></font><font style="display:inline;"></font><font style="display:inline;;font-size: 10pt;font-family:Times New Roman,Times,serif;text-indent:0pt;margin-left:0pt;padding:0pt 36pt 0pt 0pt;"></font><font style="display:inline;"></font><font style="display:inline;;font-size: 10pt;font-family:Times New Roman,Times,serif;text-indent:0pt;margin-left:0pt;padding:0pt 36pt 0pt 0pt;"></font><font style="display:inline;"></font><font style="display:inline;;font-size: 10pt;font-family:Times New Roman,Times,serif;text-indent:0pt;margin-left:0pt;padding:0pt 36pt 0pt 0pt;"></font><font style="display:inline;"></font><font style="display:inline;;font-size: 10pt;font-family:Times New Roman,Times,serif;text-indent:0pt;margin-left:0pt;padding:0pt 36pt 0pt 0pt;"></font><font style="display:inline;"></font><font style="display:inline;;font-size: 10pt;font-family:Times New Roman,Times,serif;text-indent:0pt;margin-left:0pt;padding:0pt 36pt 0pt 0pt;"></font><font style="display:inline;"></font><font style="display:inline;;font-size: 10pt;font-family:Times New Roman,Times,serif;text-indent:0pt;margin-left:0pt;padding:0pt 36pt 0pt 0pt;"></font><font style="display:inline;"></font><font style="display:inline;;font-size: 10pt;font-family:Times New Roman,Times,serif;text-indent:0pt;margin-left:0pt;padding:0pt 36pt 0pt 0pt;"></font><font style="display:inline;"></font><font style="display:inline;;font-size: 10pt;font-family:Times New Roman,Times,serif;text-indent:0pt;margin-left:0pt;padding:0pt 36pt 0pt 0pt;"></font><font style="display:inline;"></font><font style="display:inline;;font-size: 10pt;font-family:Times New Roman,Times,serif;text-indent:0pt;margin-left:0pt;padding:0pt 36pt 0pt 0pt;"></font><font style="display:inline;"></font><font style="display:inline;;font-size: 10pt;font-family:Times New Roman,Times,serif;text-indent:0pt;margin-left:0pt;padding:0pt 36pt 0pt 0pt;"></font><font style="display:inline;"></font><font style="display:inline;"></font>
</p>
<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;"> </font>
</p>
<div style="width:100%;"><table cellpadding="0" cellspacing="0" style="border-collapse:collapse;width: 100.00%;margin-left:0pt;">
<tr>
<td valign="bottom" style="width:70.00%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 8pt;">
<font style="display:inline;font-size:8pt;"> </font></p>
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td colspan="5" valign="bottom" style="width:26.50%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman,Times,serif;font-size: 8pt;">
<font style="display:inline;font-weight:bold;font-size:8pt;">Three Months Ended March 31,</font></p>
</td>
<td valign="bottom" style="width:01.00%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
</tr>
<tr>
<td valign="bottom" style="width:70.00%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 8pt;">
<font style="display:inline;font-weight:bold;font-size:8pt;">(In thousands)</font></p>
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td colspan="2" valign="bottom" style="width:12.00%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman,Times,serif;font-size: 8pt;">
<font style="display:inline;font-weight:bold;font-size:8pt;">2016</font></p>
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td colspan="2" valign="bottom" style="width:12.00%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman,Times,serif;font-size: 8pt;">
<font style="display:inline;font-weight:bold;font-size:8pt;">2015</font></p>
</td>
<td valign="bottom" style="width:01.00%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
</tr>
<tr>
<td valign="top" style="width:70.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10.1pt;line-height:106.67%;text-indent: -10.1pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">Mylan</font></p>
</td>
<td valign="bottom" style="width:02.50%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td valign="bottom" style="width:01.12%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">$</font></p>
</td>
<td valign="bottom" style="width:10.88%;background-color: #CCEEFF;;font-family:Times New Roman,Times,serif;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>31,173
</td>
<td valign="bottom" style="width:02.50%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td valign="bottom" style="width:01.12%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">$</font></p>
</td>
<td valign="bottom" style="width:10.88%;background-color: #CCEEFF;;font-family:Times New Roman,Times,serif;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>4,132
</td>
<td valign="bottom" style="width:01.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
</tr>
<tr>
<td valign="top" style="width:70.00%;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10.1pt;line-height:106.67%;text-indent: -10.1pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">Alfa Wassermann</font></p>
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td colspan="2" valign="bottom" style="width:12.00%;;font-family:Times New Roman,Times,serif;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>1,185
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td colspan="2" valign="bottom" style="width:12.00%;;font-family:Times New Roman,Times,serif;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>422
</td>
<td valign="bottom" style="width:01.00%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
</tr>
<tr>
<td valign="top" style="width:70.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10.1pt;line-height:106.67%;text-indent: -10.1pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">R-Pharm</font></p>
</td>
<td valign="bottom" style="width:02.50%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td colspan="2" valign="bottom" style="width:12.00%;background-color: #CCEEFF;;font-family:Times New Roman,Times,serif;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>14
</td>
<td valign="bottom" style="width:02.50%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td colspan="2" valign="bottom" style="width:12.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:right;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">—</font></p>
</td>
<td valign="bottom" style="width:01.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
</tr>
<tr>
<td valign="top" style="width:70.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td valign="bottom" style="width:02.50%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td colspan="2" valign="bottom" style="width:12.00%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td valign="bottom" style="width:02.50%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td colspan="2" valign="bottom" style="width:12.00%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td valign="bottom" style="width:01.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
</tr>
<tr>
<td valign="top" style="width:70.00%;padding:0pt;">
<p style="margin:0pt 0pt 0pt 20.2pt;line-height:106.67%;text-indent: -10.1pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">Total reduction to R&D costs</font></p>
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td valign="bottom" style="width:01.12%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">$</font></p>
</td>
<td valign="bottom" style="width:10.88%;;font-family:Times New Roman,Times,serif;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>32,372
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td valign="bottom" style="width:01.12%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">$</font></p>
</td>
<td valign="bottom" style="width:10.86%;;font-family:Times New Roman,Times,serif;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>4,554
</td>
<td valign="bottom" style="width:01.00%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
</tr>
<tr>
<td valign="top" style="width:70.00%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td valign="bottom" style="width:01.12%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:2pt double #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td valign="bottom" style="width:10.88%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:2pt double #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td valign="bottom" style="width:01.12%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:2pt double #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td valign="bottom" style="width:10.86%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:2pt double #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td valign="bottom" style="width:01.00%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
</tr>
</table></div>
<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;"> </font>
</p></div><div style="margin-left:0%;margin-right:0%;">
<p><font size="1"> </font></p></div><div style="margin-left:0%;margin-right:0%;"></div> </div>
36019000
35678000
833000
833000
-321556000
-363706000
20401000
18410000
1280000
3311000
<div> <div style="margin-left:0%;margin-right:0%;"></div><div style="margin-left:0%;margin-right:0%;">
<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="font-size: 10pt;font-family:Times New Roman,Times,serif;text-indent:0pt;margin-left:0pt;padding:0pt 36pt 0pt 0pt;"></font><font style="display:inline;"></font><font style="display:inline;;font-size: 10pt;font-family:Times New Roman,Times,serif;text-indent:0pt;margin-left:0pt;padding:0pt 36pt 0pt 0pt;"></font><font style="display:inline;"></font><font style="display:inline;;font-size: 10pt;font-family:Times New Roman,Times,serif;text-indent:0pt;margin-left:0pt;padding:0pt 36pt 0pt 0pt;"></font><font style="display:inline;"></font><font style="display:inline;;font-size: 10pt;font-family:Times New Roman,Times,serif;text-indent:0pt;margin-left:0pt;padding:0pt 36pt 0pt 0pt;"></font><font style="display:inline;"></font><font style="display:inline;;font-size: 10pt;font-family:Times New Roman,Times,serif;text-indent:0pt;margin-left:0pt;padding:0pt 36pt 0pt 0pt;"></font><font style="display:inline;"></font><font style="display:inline;;font-size: 10pt;font-family:Times New Roman,Times,serif;text-indent:0pt;margin-left:0pt;padding:0pt 36pt 0pt 0pt;"></font><font style="display:inline;"></font><font style="display:inline;;font-size: 10pt;font-family:Times New Roman,Times,serif;text-indent:0pt;margin-left:0pt;padding:0pt 36pt 0pt 0pt;"></font><font style="display:inline;"></font><font style="display:inline;;font-size: 10pt;font-family:Times New Roman,Times,serif;text-indent:0pt;margin-left:0pt;padding:0pt 36pt 0pt 0pt;"></font><font style="display:inline;"></font><font style="display:inline;;font-size: 10pt;font-family:Times New Roman,Times,serif;text-indent:0pt;margin-left:0pt;padding:0pt 36pt 0pt 0pt;"></font><font style="display:inline;"></font><font style="display:inline;;font-size: 10pt;font-family:Times New Roman,Times,serif;text-indent:0pt;margin-left:0pt;padding:0pt 36pt 0pt 0pt;"></font><font style="display:inline;"></font><font style="display:inline;;font-size: 10pt;font-family:Times New Roman,Times,serif;text-indent:0pt;margin-left:0pt;padding:0pt 36pt 0pt 0pt;"></font><font style="display:inline;"></font><font style="display:inline;;font-size: 10pt;font-family:Times New Roman,Times,serif;text-indent:0pt;margin-left:0pt;padding:0pt 36pt 0pt 0pt;"></font><font style="display:inline;"></font><font style="display:inline;;font-size: 10pt;font-family:Times New Roman,Times,serif;text-indent:0pt;margin-left:0pt;padding:0pt 36pt 0pt 0pt;"></font><font style="display:inline;"></font><font style="display:inline;;font-size: 10pt;font-family:Times New Roman,Times,serif;text-indent:0pt;margin-left:0pt;padding:0pt 36pt 0pt 0pt;"></font><font style="display:inline;"></font><font style="display:inline;;font-size: 10pt;font-family:Times New Roman,Times,serif;text-indent:0pt;margin-left:0pt;padding:0pt 36pt 0pt 0pt;"></font><font style="display:inline;"></font><font style="display:inline;;font-size: 10pt;font-family:Times New Roman,Times,serif;text-indent:0pt;margin-left:0pt;padding:0pt 36pt 0pt 0pt;"></font><font style="display:inline;"></font><font style="display:inline;;font-size: 10pt;font-family:Times New Roman,Times,serif;text-indent:0pt;margin-left:0pt;padding:0pt 36pt 0pt 0pt;"></font><font style="display:inline;"></font><font style="display:inline;;font-size: 10pt;font-family:Times New Roman,Times,serif;text-indent:0pt;margin-left:0pt;padding:0pt 36pt 0pt 0pt;"></font><font style="display:inline;"></font><font style="display:inline;"></font>
</p>
<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;"> </font>
</p>
<div style="width:100%;"><table cellpadding="0" cellspacing="0" style="border-collapse:collapse;width: 100.00%;margin-left:0pt;">
<tr>
<td valign="bottom" style="width:70.00%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 8pt;">
<font style="display:inline;font-size:8pt;"> </font></p>
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td colspan="3" valign="bottom" style="width:26.50%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman,Times,serif;font-size: 8pt;">
<font style="display:inline;font-weight:bold;font-size:8pt;">Three Months Ended March 31,</font></p>
</td>
<td valign="bottom" style="width:01.00%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
</tr>
<tr>
<td valign="bottom" style="width:70.00%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 8pt;">
<font style="display:inline;font-weight:bold;font-size:8pt;">(In thousands)</font></p>
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td valign="bottom" style="width:12.00%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman,Times,serif;font-size: 8pt;">
<font style="display:inline;font-weight:bold;font-size:8pt;">2016</font></p>
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td valign="bottom" style="width:12.00%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman,Times,serif;font-size: 8pt;">
<font style="display:inline;font-weight:bold;font-size:8pt;">2015</font></p>
</td>
<td valign="bottom" style="width:01.00%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
</tr>
<tr>
<td valign="top" style="width:70.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10.1pt;line-height:106.67%;text-indent: -10.1pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">Share issuances under equity incentive plan and ESPP</font></p>
</td>
<td valign="bottom" style="width:02.50%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td valign="bottom" style="width:12.00%;background-color: #CCEEFF;;font-family:Times New Roman,Times,serif;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>4,136
</td>
<td valign="bottom" style="width:02.50%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td valign="bottom" style="width:12.00%;background-color: #CCEEFF;;font-family:Times New Roman,Times,serif;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>4,353
</td>
<td valign="bottom" style="width:01.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
</tr>
<tr>
<td valign="top" style="width:70.00%;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10.1pt;line-height:106.67%;text-indent: -10.1pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">Restricted shares</font></p>
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td valign="bottom" style="width:12.00%;;font-family:Times New Roman,Times,serif;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>1,497
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td valign="bottom" style="width:12.00%;;font-family:Times New Roman,Times,serif;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>395
</td>
<td valign="bottom" style="width:01.00%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
</tr>
<tr>
<td valign="top" style="width:70.00%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td valign="bottom" style="width:12.00%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td valign="bottom" style="width:12.00%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td valign="bottom" style="width:01.00%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
</tr>
<tr>
<td valign="top" style="width:70.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10.1pt;line-height:106.67%;text-indent: -10.1pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;"> </font></p>
</td>
<td valign="bottom" style="width:02.50%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td valign="bottom" style="width:12.00%;background-color: #CCEEFF;;font-family:Times New Roman,Times,serif;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>5,633
</td>
<td valign="bottom" style="width:02.50%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td valign="bottom" style="width:12.00%;background-color: #CCEEFF;;font-family:Times New Roman,Times,serif;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>4,748
</td>
<td valign="bottom" style="width:01.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
</tr>
<tr>
<td valign="top" style="width:70.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td valign="bottom" style="width:02.50%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td valign="bottom" style="width:12.00%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:2pt double #000000 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td valign="bottom" style="width:02.50%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td valign="bottom" style="width:12.00%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:2pt double #000000 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td valign="bottom" style="width:01.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
</tr>
</table></div>
<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;"> </font>
</p></div><div style="margin-left:0%;margin-right:0%;">
<p><font size="1"> </font></p></div><div style="margin-left:0%;margin-right:0%;"></div> </div>
<div> <div style="margin-left:0%;margin-right:0%;"></div><div style="margin-left:0%;margin-right:0%;">
<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="font-size: 10pt;font-family:Times New Roman,Times,serif;text-indent:0pt;margin-left:0pt;padding:0pt 36pt 0pt 0pt;"></font><font style="display:inline;"></font><font style="display:inline;;font-size: 10pt;font-family:Times New Roman,Times,serif;text-indent:0pt;margin-left:0pt;padding:0pt 36pt 0pt 0pt;"></font><font style="display:inline;"></font><font style="display:inline;;font-size: 10pt;font-family:Times New Roman,Times,serif;text-indent:0pt;margin-left:0pt;padding:0pt 36pt 0pt 0pt;"></font><font style="display:inline;"></font><font style="display:inline;;font-size: 10pt;font-family:Times New Roman,Times,serif;text-indent:0pt;margin-left:0pt;padding:0pt 36pt 0pt 0pt;"></font><font style="display:inline;"></font><font style="display:inline;;font-size: 10pt;font-family:Times New Roman,Times,serif;text-indent:0pt;margin-left:0pt;padding:0pt 36pt 0pt 0pt;"></font><font style="display:inline;"></font><font style="display:inline;;font-size: 10pt;font-family:Times New Roman,Times,serif;text-indent:0pt;margin-left:0pt;padding:0pt 36pt 0pt 0pt;"></font><font style="display:inline;"></font><font style="display:inline;;font-size: 10pt;font-family:Times New Roman,Times,serif;text-indent:0pt;margin-left:0pt;padding:0pt 36pt 0pt 0pt;"></font><font style="display:inline;"></font><font style="display:inline;;font-size: 10pt;font-family:Times New Roman,Times,serif;text-indent:0pt;margin-left:0pt;padding:0pt 36pt 0pt 0pt;"></font><font style="display:inline;"></font><font style="display:inline;;font-size: 10pt;font-family:Times New Roman,Times,serif;text-indent:0pt;margin-left:0pt;padding:0pt 36pt 0pt 0pt;"></font><font style="display:inline;"></font><font style="display:inline;;font-size: 10pt;font-family:Times New Roman,Times,serif;text-indent:0pt;margin-left:0pt;padding:0pt 36pt 0pt 0pt;"></font><font style="display:inline;"></font><font style="display:inline;;font-size: 10pt;font-family:Times New Roman,Times,serif;text-indent:0pt;margin-left:0pt;padding:0pt 36pt 0pt 0pt;"></font><font style="display:inline;"></font><font style="display:inline;;font-size: 10pt;font-family:Times New Roman,Times,serif;text-indent:0pt;margin-left:0pt;padding:0pt 36pt 0pt 0pt;"></font><font style="display:inline;"></font><font style="display:inline;;font-size: 10pt;font-family:Times New Roman,Times,serif;text-indent:0pt;margin-left:0pt;padding:0pt 36pt 0pt 0pt;"></font><font style="display:inline;"></font><font style="display:inline;;font-size: 10pt;font-family:Times New Roman,Times,serif;text-indent:0pt;margin-left:0pt;padding:0pt 36pt 0pt 0pt;"></font><font style="display:inline;"></font><font style="display:inline;;font-size: 10pt;font-family:Times New Roman,Times,serif;text-indent:0pt;margin-left:0pt;padding:0pt 36pt 0pt 0pt;"></font><font style="display:inline;"></font><font style="display:inline;;font-size: 10pt;font-family:Times New Roman,Times,serif;text-indent:0pt;margin-left:0pt;padding:0pt 36pt 0pt 0pt;"></font><font style="display:inline;"></font><font style="display:inline;;font-size: 10pt;font-family:Times New Roman,Times,serif;text-indent:0pt;margin-left:0pt;padding:0pt 36pt 0pt 0pt;"></font><font style="display:inline;"></font><font style="display:inline;"></font>
</p>
<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;"> </font>
</p>
<div style="width:100%;"><table cellpadding="0" cellspacing="0" style="border-collapse:collapse;width: 100.00%;margin-left:0pt;">
<tr>
<td valign="bottom" style="width:70.00%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 8pt;">
<font style="display:inline;font-size:8pt;"> </font></p>
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td colspan="5" valign="bottom" style="width:26.50%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman,Times,serif;font-size: 8pt;">
<font style="display:inline;font-weight:bold;font-size:8pt;">Three Months Ended March 31,</font></p>
</td>
<td valign="bottom" style="width:01.00%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
</tr>
<tr>
<td valign="bottom" style="width:70.00%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 8pt;">
<font style="display:inline;font-weight:bold;font-size:8pt;">(In thousands)</font></p>
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td colspan="2" valign="bottom" style="width:12.00%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman,Times,serif;font-size: 8pt;">
<font style="display:inline;font-weight:bold;font-size:8pt;">2016</font></p>
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td colspan="2" valign="bottom" style="width:12.00%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman,Times,serif;font-size: 8pt;">
<font style="display:inline;font-weight:bold;font-size:8pt;">2015</font></p>
</td>
<td valign="bottom" style="width:01.00%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
</tr>
<tr>
<td valign="top" style="width:70.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10.1pt;line-height:106.67%;text-indent: -10.1pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">Research and development</font></p>
</td>
<td valign="bottom" style="width:02.50%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td valign="bottom" style="width:01.12%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">$</font></p>
</td>
<td valign="bottom" style="width:10.88%;background-color: #CCEEFF;;font-family:Times New Roman,Times,serif;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>5,160
</td>
<td valign="bottom" style="width:02.50%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td valign="bottom" style="width:01.12%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">$</font></p>
</td>
<td valign="bottom" style="width:10.88%;background-color: #CCEEFF;;font-family:Times New Roman,Times,serif;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>7,482
</td>
<td valign="bottom" style="width:01.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
</tr>
<tr>
<td valign="top" style="width:70.00%;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10.1pt;line-height:106.67%;text-indent: -10.1pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">Selling, general and administrative</font></p>
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td colspan="2" valign="bottom" style="width:12.00%;;font-family:Times New Roman,Times,serif;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>6,170
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td colspan="2" valign="bottom" style="width:12.00%;;font-family:Times New Roman,Times,serif;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>8,144
</td>
<td valign="bottom" style="width:01.00%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
</tr>
<tr>
<td valign="top" style="width:70.00%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td colspan="2" valign="bottom" style="width:12.00%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td colspan="2" valign="bottom" style="width:12.00%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td valign="bottom" style="width:01.00%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
</tr>
<tr>
<td valign="top" style="width:70.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt 0pt 0pt 20.2pt;line-height:106.67%;text-indent: -10.1pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">Total share-based compensation expense</font></p>
</td>
<td valign="bottom" style="width:02.50%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td valign="bottom" style="width:01.12%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">$</font></p>
</td>
<td valign="bottom" style="width:10.88%;background-color: #CCEEFF;;font-family:Times New Roman,Times,serif;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>11,330
</td>
<td valign="bottom" style="width:02.50%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td valign="bottom" style="width:01.12%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">$</font></p>
</td>
<td valign="bottom" style="width:10.86%;background-color: #CCEEFF;;font-family:Times New Roman,Times,serif;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>15,626
</td>
<td valign="bottom" style="width:01.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
</tr>
<tr>
<td valign="top" style="width:70.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td valign="bottom" style="width:02.50%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td valign="bottom" style="width:01.12%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:2pt double #000000 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td valign="bottom" style="width:10.88%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:2pt double #000000 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td valign="bottom" style="width:02.50%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td valign="bottom" style="width:01.12%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:2pt double #000000 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td valign="bottom" style="width:10.86%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:2pt double #000000 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td valign="bottom" style="width:01.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
</tr>
</table></div>
<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;"> </font>
</p></div><div style="margin-left:0%;margin-right:0%;">
<p><font size="1"> </font></p></div><div style="margin-left:0%;margin-right:0%;"></div> </div>
<div> <div style="margin-left:0%;margin-right:0%;"></div><div style="margin-left:0%;margin-right:0%;">
<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="font-size: 10pt;font-family:Times New Roman,Times,serif;text-indent:0pt;margin-left:0pt;padding:0pt 36pt 0pt 0pt;"></font><font style="display:inline;"></font><font style="display:inline;;font-size: 10pt;font-family:Times New Roman,Times,serif;text-indent:0pt;margin-left:0pt;padding:0pt 36pt 0pt 0pt;"></font><font style="display:inline;"></font><font style="display:inline;;font-size: 10pt;font-family:Times New Roman,Times,serif;text-indent:0pt;margin-left:0pt;padding:0pt 36pt 0pt 0pt;"></font><font style="display:inline;"></font><font style="display:inline;;font-size: 10pt;font-family:Times New Roman,Times,serif;text-indent:0pt;margin-left:0pt;padding:0pt 36pt 0pt 0pt;"></font><font style="display:inline;"></font><font style="display:inline;;font-size: 10pt;font-family:Times New Roman,Times,serif;text-indent:0pt;margin-left:0pt;padding:0pt 36pt 0pt 0pt;"></font><font style="display:inline;"></font><font style="display:inline;;font-size: 10pt;font-family:Times New Roman,Times,serif;text-indent:0pt;margin-left:0pt;padding:0pt 36pt 0pt 0pt;"></font><font style="display:inline;"></font><font style="display:inline;;font-size: 10pt;font-family:Times New Roman,Times,serif;text-indent:0pt;margin-left:0pt;padding:0pt 36pt 0pt 0pt;"></font><font style="display:inline;"></font><font style="display:inline;;font-size: 10pt;font-family:Times New Roman,Times,serif;text-indent:0pt;margin-left:0pt;padding:0pt 36pt 0pt 0pt;"></font><font style="display:inline;"></font><font style="display:inline;;font-size: 10pt;font-family:Times New Roman,Times,serif;text-indent:0pt;margin-left:0pt;padding:0pt 36pt 0pt 0pt;"></font><font style="display:inline;"></font><font style="display:inline;;font-size: 10pt;font-family:Times New Roman,Times,serif;text-indent:0pt;margin-left:0pt;padding:0pt 36pt 0pt 0pt;"></font><font style="display:inline;"></font><font style="display:inline;;font-size: 10pt;font-family:Times New Roman,Times,serif;text-indent:0pt;margin-left:0pt;padding:0pt 36pt 0pt 0pt;"></font><font style="display:inline;"></font><font style="display:inline;;font-size: 10pt;font-family:Times New Roman,Times,serif;text-indent:0pt;margin-left:0pt;padding:0pt 36pt 0pt 0pt;"></font><font style="display:inline;"></font><font style="display:inline;;font-size: 10pt;font-family:Times New Roman,Times,serif;text-indent:0pt;margin-left:0pt;padding:0pt 36pt 0pt 0pt;"></font><font style="display:inline;"></font><font style="display:inline;;font-size: 10pt;font-family:Times New Roman,Times,serif;text-indent:0pt;margin-left:0pt;padding:0pt 36pt 0pt 0pt;"></font><font style="display:inline;"></font><font style="display:inline;;font-size: 10pt;font-family:Times New Roman,Times,serif;text-indent:0pt;margin-left:0pt;padding:0pt 36pt 0pt 0pt;"></font><font style="display:inline;"></font><font style="display:inline;;font-size: 10pt;font-family:Times New Roman,Times,serif;text-indent:0pt;margin-left:0pt;padding:0pt 36pt 0pt 0pt;"></font><font style="display:inline;"></font><font style="display:inline;;font-size: 10pt;font-family:Times New Roman,Times,serif;text-indent:0pt;margin-left:0pt;padding:0pt 36pt 0pt 0pt;"></font><font style="display:inline;"></font><font style="display:inline;"></font>
</p>
<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;"> </font>
</p>
<div style="width:100%;"><table cellpadding="0" cellspacing="0" style="border-collapse:collapse;width: 100.00%;margin-left:0pt;">
<tr>
<td valign="bottom" style="width:70.00%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 8pt;">
<font style="display:inline;font-weight:bold;font-size:8pt;">(In thousands)</font></p>
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td colspan="2" valign="bottom" style="width:12.00%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman,Times,serif;font-size: 8pt;">
<font style="display:inline;font-weight:bold;font-size:8pt;">March 31,</font><br /><font style="display:inline;font-weight:bold;font-size:8pt;">2016</font></p>
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td colspan="2" valign="bottom" style="width:12.00%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman,Times,serif;font-size: 8pt;">
<font style="display:inline;font-weight:bold;font-size:8pt;">December 31,</font><br /><font style="display:inline;font-weight:bold;font-size:8pt;">2015</font></p>
</td>
<td valign="bottom" style="width:01.00%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:center;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
</tr>
<tr>
<td valign="top" style="width:70.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10.1pt;line-height:106.67%;text-indent: -10.1pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">Raw materials</font></p>
</td>
<td valign="bottom" style="width:02.50%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td valign="bottom" style="width:01.12%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">$</font></p>
</td>
<td valign="bottom" style="width:10.88%;background-color: #CCEEFF;;font-family:Times New Roman,Times,serif;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>5,270
</td>
<td valign="bottom" style="width:02.50%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td valign="bottom" style="width:01.12%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">$</font></p>
</td>
<td valign="bottom" style="width:10.88%;background-color: #CCEEFF;;font-family:Times New Roman,Times,serif;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>6,869
</td>
<td valign="bottom" style="width:01.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
</tr>
<tr>
<td valign="top" style="width:70.00%;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10.1pt;line-height:106.67%;text-indent: -10.1pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">Work-in-process</font></p>
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td colspan="2" valign="bottom" style="width:12.00%;;font-family:Times New Roman,Times,serif;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>1,758
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td colspan="2" valign="bottom" style="width:12.00%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;text-align:right;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">—</font></p>
</td>
<td valign="bottom" style="width:01.00%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
</tr>
<tr>
<td valign="top" style="width:70.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt 0pt 0pt 10.1pt;line-height:106.67%;text-indent: -10.1pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">Finished goods</font></p>
</td>
<td valign="bottom" style="width:02.50%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td colspan="2" valign="bottom" style="width:12.00%;background-color: #CCEEFF;;font-family:Times New Roman,Times,serif;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>2,378
</td>
<td valign="bottom" style="width:02.50%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td colspan="2" valign="bottom" style="width:12.00%;background-color: #CCEEFF;;font-family:Times New Roman,Times,serif;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>3,136
</td>
<td valign="bottom" style="width:01.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
</tr>
<tr>
<td valign="top" style="width:70.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td valign="bottom" style="width:02.50%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td colspan="2" valign="bottom" style="width:12.00%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td valign="bottom" style="width:02.50%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td colspan="2" valign="bottom" style="width:12.00%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:1pt solid #000000 ;border-right:1pt none #D9D9D9 ;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
<td valign="bottom" style="width:01.00%;background-color: #CCEEFF;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
</td>
</tr>
<tr>
<td valign="top" style="width:70.00%;padding:0pt;">
<p style="margin:0pt 0pt 0pt 20.2pt;line-height:106.67%;text-indent: -10.1pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">Total inventories</font></p>
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td valign="bottom" style="width:01.12%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">$</font></p>
</td>
<td valign="bottom" style="width:10.88%;;font-family:Times New Roman,Times,serif;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>9,406
</td>
<td valign="bottom" style="width:02.50%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
<td valign="bottom" style="width:01.12%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">$</font></p>
</td>
<td valign="bottom" style="width:10.88%;;font-family:Times New Roman,Times,serif;font-size:10pt;text-align:right;" nowrap="nowrap"><div style="float:left"></div>10,005
</td>
<td valign="bottom" style="width:01.00%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 10pt;">
</p>
</td>
</tr>
<tr>
<td valign="top" style="width:70.00%;padding:0pt;">
<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
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<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
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<td valign="bottom" style="width:01.12%;border-top:1pt none #D9D9D9 ;border-left:1pt none #D9D9D9 ;border-bottom:2pt double #000000 ;border-right:1pt none #D9D9D9 ;padding:0pt;">
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<font style="display:inline;font-size:1pt;"> </font></p>
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<font style="display:inline;font-size:1pt;"> </font></p>
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<font style="display:inline;font-size:1pt;"> </font></p>
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<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
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<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
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<p style="margin:0pt;line-height:106.67%;font-family:Times New Roman,Times,serif;font-size: 1pt;">
<font style="display:inline;font-size:1pt;"> </font></p>
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<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;"> </font>
</p></div><div style="margin-left:0%;margin-right:0%;">
<p><font size="1"> </font></p></div><div style="margin-left:0%;margin-right:0%;"></div> </div>
21748000
23596000
15626000
11330000
P5Y
1575000
135000
18.918
17.70
18.48
19.53
21.00
243065000
238537000
<div> <div style="margin-left:0%;margin-right:0%;"></div><div style="margin-left:0%;margin-right:0%;">
<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;"> </font>
</p>
<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;font-weight:bold;">8. Shareholders’ Equity</font>
</p>
<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;"> </font>
</p>
<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;font-weight:bold;font-style:italic;">Purchases of Ordinary Shares by GSK</font>
</p>
<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;"> </font>
</p>
<p style="margin:0pt;text-indent:36pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">On March 17, 2016, </font><font style="display:inline;">GSK </font><font style="display:inline;">purchased 1,301,015 of our unregistered ordinary shares at a per share price of $17.70 pursuant to an Ordinary Share Purchase Agreement between the Company and GSK, dated as of March 14, 2016. The aggregate gross proceeds of the purchase were approximately $23.0 million. As of March 31, 2016, GSK beneficially owned approximately 23.3% of our outstanding ordinary shares.</font>
</p>
<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;"> </font>
</p>
<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;font-weight:bold;font-style:italic;">Ordinary Shares Issuance under At-the-Market Agreement</font>
</p>
<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;"> </font>
</p>
<p style="margin:0pt;text-indent:36pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">Pursuant to a sales agreement with Cantor Fitzgerald & Co. (“Cantor Fitzgerald”), we may issue and sell up to $50 million of our ordinary shares pursuant to an at-the-market offering program (“ATM Agreement”), under our shelf registration statement on Form S-3 effective in July 2015. Under the ATM Agreement, we pay </font><font style="display:inline;">Cantor Fitzgerald a commission rate of up to 3.0% of the gross proceeds from the sale of our ordinary shares.</font>
</p>
<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;"> </font>
</p>
<p style="margin:0pt;text-indent:36pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">We engaged in sales of our ordinary shares under the ATM Agreement from March 17, 2016 to April 8, 2016. During this period, we sold approximately 770,000 shares at an average price of $19.53 per share, resulting in aggregate net proceeds of approximately $14.6 million. For the three months ended March 31, 2016, we sold approximately 280,000 shares at an average price of $18.48 per share, resulting in aggregate net proceeds of approximately $5.0 million.</font>
</p>
<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;"> </font>
</p></div><div style="margin-left:0%;margin-right:0%;">
<p><font size="1"> </font></p></div><div style="margin-left:0%;margin-right:0%;"></div> </div>
280000
1301015
770000
5479750
<div> <div style="margin-left:0%;margin-right:0%;"></div><div style="margin-left:0%;margin-right:0%;">
<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;"> </font>
</p>
<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;font-weight:bold;">10. Subsequent Events</font>
</p>
<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;"> </font>
</p>
<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;font-weight:bold;font-style:italic;">Public Offering of Ordinary Shares</font>
</p>
<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;"> </font>
</p>
<p style="margin:0pt;text-indent:36pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;">On May 4, 2016, we closed the sale of an aggregate of 5,479,750 of our ordinary shares, $0.00001 par value, at a public offering price of $21.00 per share. The shares were issued pursuant to a prospectus supplement filed with the SEC on April 28, 2016, in connection with a takedown from our shelf registration statement on Form S-3. We received net offering proceeds of approximately $107.7 million after deducting the underwriting discount and estimated offering expenses.</font>
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<p style="margin:0pt;font-family:Times New Roman,Times,serif;font-size: 10pt;">
<font style="display:inline;"> </font>
</p></div><div style="margin-left:0%;margin-right:0%;">
<p><font size="1"> </font></p></div><div style="margin-left:0%;margin-right:0%;"></div> </div>
32830000
38326000