

<!-- Created by Merrill Corporation -->
<!--XBRL document created with Merrill Bridge  6.0.103.0 -->
<!--Based on XBRL 2.1-->
<!--Created on: 11/12/2015 1:17:32 AM-->
<!--Modified on: 11/12/2015 1:17:32 AM-->
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  <element id="tbph_SaleOfStockPricePerSharePremiumPercentage" name="SaleOfStockPricePerSharePremiumPercentage" nillable="true" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="tbph_ConsecutiveTradingDays" name="ConsecutiveTradingDays" nillable="true" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="tbph_SaleOfStockPremiumProceeds" name="SaleOfStockPremiumProceeds" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="tbph_CollaborationArrangementPotentialMilestonePayments" name="CollaborationArrangementPotentialMilestonePayments" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="tbph_CollaborationArrangementUpfrontPayment" name="CollaborationArrangementUpfrontPayment" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="tbph_AccruedClinicalAndDevelopmentExpensesCurrent" name="AccruedClinicalAndDevelopmentExpensesCurrent" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="credit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="tbph_IncreaseDecreaseInReceivablesFromCollaborationPartners" name="IncreaseDecreaseInReceivablesFromCollaborationPartners" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="tbph_ProceedsFromSaleOfOrdinarySharesToMylanNetOfPremium" name="ProceedsFromSaleOfOrdinarySharesToMylanNetOfPremium" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="tbph_MarketableSecuritiesAndFairValueMeasurementsDisclosureAbstract" name="MarketableSecuritiesAndFairValueMeasurementsDisclosureAbstract" nillable="true" type="xbrli:stringItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="tbph_MarketableSecuritiesAndFairValueMeasurementsTextBlock" name="MarketableSecuritiesAndFairValueMeasurementsTextBlock" nillable="true" type="nonnum:textBlockItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="tbph_CollaborativeAgreementNumberOfUnitsOfAccountingToWhichUpfrontPaymentWasAllocated" name="CollaborativeAgreementNumberOfUnitsOfAccountingToWhichUpfrontPaymentWasAllocated" nillable="true" type="xbrli:integerItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="tbph_SciClonePharmaceuticalsMember" name="SciClonePharmaceuticalsMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="tbph_RegulatoryMilestonePaymentReceivable" name="RegulatoryMilestonePaymentReceivable" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="tbph_TotalReceivablesFromCollaborativeArrangements" name="TotalReceivablesFromCollaborativeArrangements" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="tbph_MarketableSecuritiesWeightedAverageContractualMaturityPeriod" name="MarketableSecuritiesWeightedAverageContractualMaturityPeriod" nillable="true" type="xbrli:durationItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="tbph_NoncashRevenueFromCollaborativeArrangements" name="NoncashRevenueFromCollaborativeArrangements" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="tbph_PaymentsForRepurchaseOfRestrictedStock" name="PaymentsForRepurchaseOfRestrictedStock" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="tbph_TrekTherapeuticsMember" name="TrekTherapeuticsMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="tbph_LicensingAgreementMember" name="LicensingAgreementMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="tbph_Ns5aInhibitorMember" name="Ns5aInhibitorMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="tbph_EquityConsiderationFairValueDisclosure" name="EquityConsiderationFairValueDisclosure" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="tbph_CollaborativeArrangementContingentPaymentsRecognized" name="CollaborativeArrangementContingentPaymentsRecognized" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xbrli:balance="credit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="tbph_RestrictedCashFairValueDisclosure" name="RestrictedCashFairValueDisclosure" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="tbph_MarketableSecuritiesCashEquivalentsAndRestrictedCashFairValueDisclosure" name="MarketableSecuritiesCashEquivalentsAndRestrictedCashFairValueDisclosure" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="tbph_EmployeeStockOptionExchangeProgramMember" name="EmployeeStockOptionExchangeProgramMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="tbph_ShareBasedCompensationArrangementByShareBasedPaymentAwardExchangeRatio" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardExchangeRatio" nillable="true" type="xbrli:pureItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="tbph_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExchangedInPeriod" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExchangedInPeriod" nillable="true" type="xbrli:sharesItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="tbph_GovernanceAgreementMember" name="GovernanceAgreementMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="tbph_MoneyMarketFundsFairValueDisclosure" name="MoneyMarketFundsFairValueDisclosure" nillable="true" type="xbrli:monetaryItemType" substitutionGroup="xbrli:item" xbrli:periodType="instant" xbrli:balance="debit" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="tbph_ProfitLossPercentageAsPerCollaborationAgreement" name="ProfitLossPercentageAsPerCollaborationAgreement" nillable="true" type="num:percentItemType" substitutionGroup="xbrli:item" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
  <element id="tbph_FundsManagedByWoodfordInvestmentManagementLLPMember" name="FundsManagedByWoodfordInvestmentManagementLLPMember" nillable="true" type="nonnum:domainItemType" substitutionGroup="xbrli:item" abstract="true" xbrli:periodType="duration" xmlns="http://www.w3.org/2001/XMLSchema" />
</xsd:schema>