UNITED STATES
SECURITIES AND EXCHANGE COMMISSION
Washington, D.C. 20549


FORM 8-K

CURRENT REPORT

Pursuant to Section 13 or 15(d) of the
Securities Exchange Act of 1934

Date of Report: March 09, 2016
(Date of earliest event reported)

Theravance Biopharma, Inc.
(Exact name of registrant as specified in its charter)

Cayman Islands
(State or other jurisdiction
of incorporation)
001-36033
(Commission File Number)
EIN 98-1226628
(IRS Employer
Identification Number)

PO Box 309, Ugland House, South Church Street, George Town, Grand Cayman, Cayman Islands
(Address of principal executive offices)
  KY1-1104
(Zip Code)

650-808-6000
(Registrant's telephone number, including area code)

Not Applicable
(Former Name or Former Address, if changed since last report)


Check the appropriate box below if the Form 8-K filing is intended to simultaneously satisfy the filing obligation of the registrant under any of the following provisions:
o Written communications pursuant to Rule 425 under the Securities Act (17 CFR 230.425)
o Soliciting material pursuant to Rule 14a-12 under the Exchange Act (17 CFR 240.14a-12)
o Pre-commencement communications pursuant to Rule 14d-2(b) under the Exchange Act (17 CFR 240.14d-2(b))
o Pre-commencement communications pursuant to Rule 13e-4(c) under the Exchange Act (17 CFR 240.13e-4(c))

Item 2.02. Results of Operations and Financial Condition

On March 9, 2016, Theravance Biopharma, Inc. issued a press release and is holding a conference call regarding its financial results for the quarter and year ended December 31, 2015. A copy of the press release is furnished as Exhibit 99.1 to this Current Report.

The information in Item 2.02 and in Item 9.01 of this Current Report on Form 8-K, including Exhibit 99.1, is being furnished and shall not be deemed "filed" for the purposes of Section 18 of the Securities Exchange Act of 1934, as amended (the "Securities Exchange Act of 1934"), or otherwise subject to the liabilities of that Section, nor shall it be incorporated by reference in any filing under the Securities Act of 1933, as amended, or the Securities Exchange Act of 1934, except as expressly set forth by specific reference in such a filing.

Item 9.01. Financial Statements and Exhibits

(d) Exhibits
            99.1       Press Release of Theravance Biopharma, Inc. dated March 09, 2016


SIGNATURE

      Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on its behalf by the undersigned hereunto duly authorized.


Dated: March 09, 2016
THERAVANCE BIOPHARMA, INC.

By:  /s/ Renee D. Gala                    
     Renee D. Gala
     Senior Vice President and Chief Financial Officer


Exhibit Index
Exhibit No. Description
99.1 Press Release of Theravance Biopharma, Inc. dated March 09, 2016

Theravance Biopharma, Inc. Reports Fourth Quarter and Full Year 2015 Financial Results

Priority Programs Advancing; Multiple Data Read-Outs in 2016

DUBLIN, IRELAND -- (Marketwired - March 09, 2016) - Theravance Biopharma, Inc. (NASDAQ: TBPH) ("Theravance Biopharma" or the "Company") today reported financial results for the fourth quarter and full year ended December 31, 2015. Revenue for the fourth quarter and full year of 2015 was $3.9 million and $42.1 million, respectively. In line with the Company's expectation, the full year 2015 operating loss excluding share-based compensation was $127.8 million, or $181.9 million including share-based compensation of $54.1 million. Cash, cash equivalents, and marketable securities totaled $215.3 million as of December 31, 2015. The year-end cash balance excludes $35.2 million in receivables from collaborative arrangements and a $15.0 million milestone payment from Mylan for recently achieving 50% enrollment in the Phase 3 twelve-month safety study of revefenacin (TD-4208).

Rick E Winningham, Chairman and Chief Executive Officer, commented: "In 2015, we made significant progress in advancing our priority programs to key inflection points, setting the stage for multiple value-creating events in 2016. We recently reported positive results, including positive biomarker data, from the Phase 1 clinical trial of our neprilysin inhibitor, and we expect to report top-line data from the full Phase 1 study in the second half of 2016. The Phase 1 trial of our GI-targeted pan-JAK inhibitor for ulcerative colitis is underway and should yield data in the first half of 2016 that could pave the way to a Phase 1b trial in patients later this year. The Phase 3 program for revefenacin in COPD recently surpassed 50% enrollment in all three studies, and the Phase 3 efficacy studies remain on track to have data read out in the third quarter of 2016. On the commercial front, with our sales force expansion completed, we look forward to building on the momentum of VIBATIV® sales we achieved in the fourth quarter of 2015. We also look forward to a PDUFA date in the second quarter of 2016 for the concurrent bacteremia indications. Looking ahead, we expect to achieve key clinical and regulatory milestones in 2016, including numerous data read-outs. We believe our Company is well-positioned to generate significant value for both patients and shareholders in the near- and long-term."

Recent Highlights

Upcoming 2016 Key Data and Regulatory Milestones

Fourth Quarter Financial Results

Revenue

Revenue for the fourth quarter of 2015 was $3.9 million, including revenue from collaborative arrangements and net product sales of VIBATIV® (telavancin). Revenue from collaborative arrangements for the fourth quarter of 2015 was $0.2 million. Net product sales of VIBATIV for the fourth quarter of 2015 was $3.7 million, consisting of net product sales in the U.S. of $3.1 million and ex-U.S. of $0.6 million.

Cost of Goods Sold

Cost of goods sold for the fourth quarter of 2015 totaled $3.2 million, which includes a charge of $1.9 million for write down of inventory due to dating of the product.

Research and Development (R&D) Expenses

R&D expenses for the fourth quarter of 2015 were $32.4 million, representing a decrease of $9.8 million compared to the same period in 2014. The decrease was primarily due to non-recurring long-term retention and incentive awards and a decrease in program-related expense due to the reimbursement of expenses associated with the Mylan collaboration for revefenacin (TD-4208). Total R&D share-based compensation expense for the fourth quarter of 2015 was $5.4 million.

Selling, General and Administrative (SG&A) Expenses

SG&A expenses for the fourth quarter of 2015 were $24.1 million, representing an increase of $2.3 million compared to the same period in 2014. The increase was primarily due to costs associated with VIBATIV commercialization. Total share-based compensation expense in SG&A for the fourth quarter of 2015 was $6.1 million.

Provision for Income Taxes

In the fourth quarter of 2015, the Company recognized an income tax provision benefit of $10.8 million primarily due to changes in the Company's transfer pricing.

Cash, Cash Equivalents and Marketable Securities

Cash, cash equivalents and marketable securities, excluding restricted cash, totaled $215.3 million as of December 31, 2015. The year-end cash balance excludes receivables from collaborative arrangements noted below and a $15.0 million milestone payment from Mylan for recently achieving 50% enrollment in the Phase 3 twelve-month safety study of revefenacin.

Receivables from Collaborative Arrangements

Certain collaborative arrangements entered into by the Company result in reimbursement of expenses in the quarter after they are incurred. Total receivables from collaborative arrangements totaled $35.2 million as of December 31, 2015, and include $33.2 million in receivables associated with the Mylan collaboration.

2016 Financial Guidance

The Company anticipates that 2016 operating loss, excluding share-based compensation, will be in the range of $120.0 to $130.0 million.

Basis of Presentation

On June 1, 2014, Innoviva, Inc. ("Innoviva") (known as Theravance, Inc. prior to January 7, 2016) separated its late-stage respiratory assets partnered with GSK from its biopharmaceutical operations (the "Spin-Off") by transferring its discovery, development and commercialization operations to Theravance Biopharma. The Spin-Off resulted in Theravance Biopharma operating as an independent, publicly-traded company.

The financial statements of Theravance Biopharma for periods prior to the Spin-Off were derived from Innoviva's historical consolidated financial statements, with expenses allocated through a specific identification basis or another reasonable allocation methodology.

Notes:
(1) Regulatory and clinical milestones as reported by GSK

Conference Call Today at 5:00 pm ET

Theravance Biopharma will hold a conference call today at 5:00 pm ET. To participate in the live call by telephone, please dial (855) 296-9648 from the U.S., or (920) 663-6266 for international callers, using the confirmation code 60136860. Those interested in listening to the conference call live via the internet may do so by visiting Theravance Biopharma's website at www.theravance.com, under the Investor Relations section, Presentations and Events. Please go to the website 15 minutes prior to the start of the call to register, download, and install any necessary audio software.

A replay of the conference call will be available on Theravance Biopharma's website for 30 days through April 9, 2016. An audio replay will also be available through 11:59 pm ET on March 16, 2016 by dialing (855) 859-2056 from the U.S., or (404) 537-3406 for international callers, and then entering confirmation code 60136860.

About Theravance Biopharma

Theravance Biopharma is a diversified biopharmaceutical company with the core purpose of creating medicines that make a difference in the lives of patients suffering from serious illness.

Our pipeline of internally discovered product candidates includes potential best-in-class medicines to address the unmet needs of patients being treated for serious conditions primarily in the acute care setting. VIBATIV® (telavancin), our first commercial product, is a once-daily dual-mechanism antibiotic approved in the U.S., Europe and certain other countries for certain difficult-to-treat infections. Revefenacin (TD-4208) is a long-acting muscarinic antagonist (LAMA) being developed as a potential once-daily, nebulized treatment for chronic obstructive pulmonary disease (COPD). Our neprilysin (NEP) inhibitor program is designed to develop selective NEP inhibitors for the treatment of a range of major cardiovascular and renal diseases, including acute and chronic heart failure, hypertension and chronic kidney diseases, such as diabetic nephropathy. Our research efforts are focused in the areas of inflammation and immunology, with the goal of designing medicines that provide targeted drug delivery to tissues in the lung and gastrointestinal tract in order to maximize patient benefit and minimize risk. The first program to emerge from this research is designed to develop GI-targeted pan-Janus kinase (JAK) inhibitors for the treatment of a range of inflammatory intestinal diseases.

In addition, we have an economic interest in future payments that may be made by Glaxo Group Limited or one of its affiliates pursuant to its agreements with Innoviva, Inc. relating to certain drug development programs, including the Closed Triple (the combination of fluticasone furoate, umeclidinium, and vilanterol).

For more information, please visit www.theravance.com.

THERAVANCE®, the Cross/Star logo, MEDICINES THAT MAKE A DIFFERENCE® and VIBATIV® are registered trademarks of the Theravance Biopharma group of companies. Trademarks, trade names or service marks of other companies appearing on this press release are the property of their respective owners.

This press release contains and the conference call will contain certain "forward-looking" statements as that term is defined in the Private Securities Litigation Reform Act of 1995 regarding, among other things, statements relating to goals, plans, objectives, expectations and future events. Theravance Biopharma intends such forward-looking statements to be covered by the safe harbor provisions for forward-looking statements contained in Section 21E of the Securities Exchange Act of 1934 and the Private Securities Litigation Reform Act of 1995. Examples of such statements include statements relating to: the Company's strategies, plans and objectives, the Company's regulatory strategies and timing of clinical studies, the potential benefits and mechanisms of action of the Company's product and product candidates, the Company's expectations for product candidates through development, potential regulatory approval and commercialization (including their potential as components of combination therapies) and the Company's expectations for product sales. These statements are based on the current estimates and assumptions of the management of Theravance Biopharma as of the date of the press release and the conference call and are subject to risks, uncertainties, changes in circumstances, assumptions and other factors that may cause the actual results of Theravance Biopharma to be materially different from those reflected in the forward-looking statements. Important factors that could cause actual results to differ materially from those indicated by such forward-looking statements include, among others, risks related to: delays or difficulties in commencing or completing clinical studies, the potential that results from clinical or non-clinical studies indicate the Company's product candidates are unsafe or ineffective (including when our product candidates are studied in combination with other compounds),the feasibility of undertaking future clinical trials for our product candidates based on FDA policies and feedback, dependence on third parties to conduct clinical studies, delays or failure to achieve and maintain regulatory approvals for product candidates, risks of collaborating with third parties to discover, develop and commercialize products, risks associated with establishing and maintaining sales, marketing and distribution capabilities with appropriate technical expertise and supporting infrastructure and risks of developing an institutional customer mix for VIBATIV® (telavancin) that meet the Company's plan for the product. Other risks affecting Theravance Biopharma are described under the heading "Risk Factors" contained in Theravance Biopharma's Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission (SEC) on November 12, 2015 and Theravance Biopharma's other filings with the SEC. In addition to the risks described above and in Theravance Biopharma's filings with the SEC, other unknown or unpredictable factors also could affect Theravance Biopharma's results. No forward-looking statements can be guaranteed and actual results may differ materially from such statements. Given these uncertainties, you should not place undue reliance on these forward-looking statements. Theravance Biopharma assumes no obligation to update its forward-looking statements on account of new information, future events or otherwise, except as required by law.

                         THERAVANCE BIOPHARMA, INC.
              CONDENSED CONSOLIDATED STATEMENTS OF OPERATIONS
                   (In thousands, except per share data)

                            Three Months Ended
                               December 31,         Year Ended December 31,
                             2015         2014         2015         2014
                         -----------  -----------  -----------  -----------
                                (Unaudited)        (Unaudited)      (1)
Revenue:
  Product sales          $     3,693  $     1,309  $     9,408  $     4,418
  Revenue from
   collaborative
   arrangements                  200          124       32,718        7,270
                         -----------  -----------  -----------  -----------
    Total revenue              3,893        1,433       42,126       11,688

Costs and expenses:
  Cost of goods sold           3,200        3,222        4,657        4,058
  Research and
   development (2)            32,403       42,192      129,165      168,522
  Selling, general and
   administrative (2)         24,064       21,772       90,203       71,647
                         -----------  -----------  -----------  -----------
    Total costs and
     expenses                 59,667       67,186      224,025      244,227
                         -----------  -----------  -----------  -----------
Loss from operations         (55,774)     (65,753)    (181,899)    (232,539)
Interest and other
 income                          110          983          631        1,865
                         -----------  -----------  -----------  -----------
Loss before income taxes     (55,664)     (64,770)    (181,268)    (230,674)
Provision for income
 taxes                       (10,836)        (460)         951        6,364
                         -----------  -----------  -----------  -----------
Net loss                 $   (44,828) $   (64,310) $  (182,219) $  (237,038)
                         ===========  ===========  ===========  ===========

Net loss per share:
  Basic and diluted net
   loss per share        $     (1.23) $     (2.02) $     (5.34) $     (7.46)
                         ===========  ===========  ===========  ===========
  Shares used to compute
   basic and diluted net
   loss per share             36,513       31,782       34,150       31,755
                         ===========  ===========  ===========  ===========



(1) The condensed consolidated statement of operations for the year ended
 December 31, 2014 has been derived from the audited consolidated financial
 statements included in the Company's Annual Report on Form 10-K for the
 fiscal year ended December 31, 2014.

(2) Amounts include share-based compensation expense as follows:

                            Three Months Ended
                               December 31,         Year Ended December 31,
(In thousands)               2015         2014         2015         2014
------------------------ -----------  -----------  -----------  -----------
Research and development $     5,437  $     7,145  $    25,770  $    21,191
Selling, general and
 administrative                6,074        7,275       28,280       22,043
                         -----------  -----------  -----------  -----------
  Total share-based
   compensation expense  $    11,511  $    14,420  $    54,050  $    43,234
                         ===========  ===========  ===========  ===========



                         THERAVANCE BIOPHARMA, INC.
                    CONDENSED CONSOLIDATED BALANCE SHEETS
                               (In thousands)

                                                         December 31,
                                                 ---------------------------
                                                      2015          2014
                                                 ------------- -------------
Assets                                            (Unaudited)       (1)
Current assets:
  Cash and cash equivalents and marketable
   securities                                    $     215,294 $     306,010
  Receivables from collaborative arrangements (2)       35,232         1,840
  Prepaid taxes                                         12,764             -
  Inventories                                           10,005        12,546
  Other prepaid and current assets                       7,037         6,373
Restricted cash                                            833           833
Property and equipment, net                              9,873         9,663
Other assets                                             9,078           506
                                                 ------------- -------------
  Total assets                                   $     300,116 $     337,771
                                                 ============= =============

Liabilities and Shareholders' Equity
Current liabilities (3)                                 49,470        41,256
Long-term liabilities                                    7,581         6,728
Shareholders' equity                                   243,065       289,787
                                                 ------------- -------------
  Total liabilities and shareholders' equity     $     300,116 $     337,771
                                                 ============= =============





(1) The condensed consolidated balance sheet at December 31, 2014 has been
 derived from the audited consolidated financial statements included in the
 Company's Annual Report on Form 10-K for the fiscal year ended December 31,
 2014.

(2) Receivables from collaborative arrangements at December 31, 2015
 includes $33.2 million in receivables associated with the Mylan
 collaboration.

(3) Amounts include the current portion of deferred revenue of $0.1 million
 at December 31, 2015 and 2014.


Contact Information:

Renee Gala
Chief Financial Officer
650-808-4045
investor.relations@theravance.com